Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2007-02-13
2007-02-13
Prouuty, Rebecca (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C435S019000, C435S069100, C435S320100, C435S325000, C435S252300, C530S350000, C536S023200, C536S023500, C424S094600
Reexamination Certificate
active
10343141
ABSTRACT:
The present invention provides novel esterase proteins, Specifically, the present invention provides proteins having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 7, or salts thereof; their partial peptides or salts thereof: DNAs encoding the proteins; recombinant vectors containing the DNAs; transformants, a method of manufacturing the proteins; pharmaceuticals comprising the proteins or DNAs; antibodies to the proteins; a method of screening compounds or salts thereof having an activity of promoting the esterase activity of the proteins; the compounds obtained by the screening; and pharmaceuticals comprising the said compounds; etc.
REFERENCES:
Witkowski et al. , Biochemistry 38:11643-11650, 1999.
Seffernick et al. , J. Bacteriol. 183(8):2405-2410, 2001.
Broun et al. , Science 282:1315-1317, 1998.
Probst et al., EMBL accession No. AAA35551, 1994.
Guo et al., PNAS 101(25):9205-9210, 2004.
Probst, et al. “Human Liver Arylacetamide Deacetylase” The Journal of Biological Chemistry 269(34): 21650-21656 (1994).
Sunahara Eiji
Taniyama Yoshio
Tozawa Ryuichi
Chao Mark
Prouuty Rebecca
Ramesh Elaine M.
Ramirez Delia M.
Takeda Pharmaceutical Company Limited
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