Isolated human phospholipase proteins, nucleic acid...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

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C435S252300, C435S320100, C536S023200

Reexamination Certificate

active

06943003

ABSTRACT:
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phospholipase peptides, and methods of identifying modulators of the phospholipase peptides.

REFERENCES:
patent: WO 01 57188 (2001-08-01), None
patent: WO 02 31161 (2002-04-01), None
patent: WO 02 59328 (2002-08-01), None
Boll W. et al. “Messenger RNAs Expressed in Intestine of Adult but Not Baby Rabbits.” Journal of Biological Chemistry, vol. 268, No. 17, Jun. 15, 1993. pp. 12901-12911. XP002200728.
Takemori et al. “Identification of Functional Domains of Rat Intestinal Phospholipase B/Lipase.” Journal of Biological Chemistry, vol. 273, No. 4, Jan. 23, 1998, pp. 2222-2231. XP002222279.
Hillier et al. “zv97h009.s1 Soares_NhHMPu_S1 Homo Sapiens cDNA Clone IMAGE: 767777 3′ Similar to SW: PHLX_RABIT Q05017 Phospholipase ADRAB-B Precursor, mRNA Sequence.” Database EMBL, Heidelberg, FRG Online! May 14, 1997. Database accession No. AA418082. XP002234814.
NCI-CGAP “UI-H-BI4-aoe-g-11-O-UI.s1 NCI_CGAP_Sub8 Homo Sapiens cDNA Clone IMAGE: 3084860 3′, mRNA Sequence.” Database EMBL, Heidelberg, FRG Online! Dec. 8, 2000. Database accession No. BF510463. XP002234815.
NCI-CGAP “he10e12.x1 NCI_CGAP_CMLI Homo Sapiens cDNA Clone Image: 2918638 3′ Similar to SW: PHLX_RABIT Q85017 Phospholipase ADRAB-B Precursor, Contains MER22.t1 MER22 Repetitive Element, mRNA Sequence.” Database EMBL, Heidelberg, FRG Online? Mar. 2, 2000. Database accession No. AW467395. XP002234816.
Dias Neto et al. “MR2_EN0091-261200-007-b04 EN0091 Homo Sapiens cDNA, mRNA Sequence.” Database EMBL, Heidelberg, FRG Online! Jan. 18, 2001. Database accession No. BF854199. XP002234817.
NCI/NINDS-CGAP: “7g10g10.x1 NCI_CGAP_Bm23 Homo Sapiens cDNA Clone IMAGE: 3306114 3′ Similar to SW: PHLX_RABIT Q05017 Phospholipase DRAB-B Precursor, Contains MER22.t1 MER22 Repetitive Element, mRNA Sequence.” Database EMBL, Heidelberg, FRG Online! Oct. 1, 2000. Database accession No. BE855594. XP002234818.
NCI-CGAP: “7e70h12.x1 NCI_CGAP_Pr28 Homo Sapiens cDNA Clone IMAGE: 3287879 3′ Similar to SW: PHLX_RABIT Q05017 Phospholipase ADRAB-B Precursor, mRNA Sequence.” Database EMBL, Heidelberg, FRG Online! Sep. 7, 2000. Database accession No. BE645470. XP002234819.
Dias Neto et al. “IL3-CT0220-031199-025-G12 CT0220 Homo Sapiens cDNA, mRNA Sequence.” Database EMBL, Heidelberg, FRG 'Online! Apr. 30, 2000. Database accession No. AW752833. XP002234820.
Dias Neto et al. “MR2-EN0091-211200-003-c02 EN0091 Homo Sapiens cDNA, mRNA Sequence.” Database EMBL, Heidelberg, FRG 'Online! Jan. 18, 2001. Database accession No. BF853588. XP002234821.
Hillier et al. “zv97h09.r1 Soares_NhHPu_S1 Homo Sapiens cDNA Clone IMAGE: 767777 5′ Similar to SW: PHLX_RABIT Q05017 PHOSPHOLIPASE ADRAB-B PRECURSOR, mRNA Sequence.” Database EMBL, Heidelberg, FRG Online! May 14, 1997. Database accession No. AA418228. XP002234822.
Dias Neto et al. “IL3-CT0220-150200-070-H02 CT0220 Homo Sapiens cDNA, mRNA Sequence.” Database EMBL, Heidelberg, FRG 'Online! May 24, 2000. Database accession No. AW851123. XP002234823.
Sulston JE and Waterson R. “Homo Sapiens BAC Clone RP11-780J6 From 2, Complete Sequence.” Database EMBL, Heidelberg, FRG 'Online! Jul. 11, 2000. Database accession No. AC074011. XP002234824.

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