Isolated human kinase proteins, nucleic acid molecules...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

Reexamination Certificate

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C424S130100, C424S133100

Reexamination Certificate

active

07112326

ABSTRACT:
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.

REFERENCES:
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patent: 6730506 (2004-05-01), Yan et al.
patent: 6900042 (2005-05-01), Yan et al.
patent: WO 99/33962 (1999-07-01), None
Database Swissprot 'Online! EBI, Hinxton, Cambridgeshire, UK; (Dec. 1, 2001) Hadano et al: “ALSCR7 Ser—thr—pkinase.” Database Accession No. Q96Q40; XP002216746.
Database EBI 'EBI, Hinxton, Cambridgeshire, UK (Dec. 7, 2000) Plowman et al: “Sequence 47 from Patent WO 00/73469 (Protein Kinases)” Database Accession No. AX056403; XP002216747.
WO 00/73469 A (Plowman) (Dec. 7, 2000).
Database EPOP 'Online! EBI, Hinxton, Cambridgeshire, UK (Dec. 7, 2000) Plowman et al: “Sequence 165 from Patent WO 00/73469 (Protein Kinases)” Database Accession No. AX056521; XP002216748.
Database EMBL Online! EBI, Hinxton, Cambridgeshire, UK; (Apr. 9, 1999) Sulston and Waterson: “Homo sapiensBAC close RP11-182H9 from 2, complete sequence.” Database Accession No. AC007242; XP002216749.
Johnston, M: “Gene chips: Array of hope for understanding gene regulation” Current Biology, vol. 8, No. 5 (Feb. 1998), pp. R171-R174 (XP000905195).
Hanks, S.K. et al:-“Use of Degenerate Oligonucleotide Probes to Identify Clones That Encode Protein Kinases” Methods in Enzymology, Academic Press Inc., vol. 200 (1991), pp. 525-532 (XP001096015).
Hanks, S.K.: “Homology probing: Identification of cDNA clones encoding members of the protein-serine kinase family” Proceedings of the National Academy of Sciences of USA, National Academy of Science, vol. 84 (Jan. 1987), pp. 388-392.
Lazzaro, M.A., et al: “A Novel cdc2 Related Protein Kinase Expressed in the Nervous System” Journal of Neurochemistry, vol. 69, No. 1 (1997), pp. 348-364 (XP002103363).

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