Isolated human kinase proteins, nucleic acid molecules...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

Reexamination Certificate

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C435S252300, C435S320100, C435S325000, C435S006120, C536S023200

Reexamination Certificate

active

06916643

ABSTRACT:
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.

REFERENCES:
Sulston et al. “Toward a Complete Human Genome Sequence.” The Sanger Centre and the Wasing University Genome Sequencing Center. Genome Research. Nov. 1998, vol. 8, No. 11, pp. 1097-1108.
Rappold G.A. “H.sapiensmRNA for Protein Kinase PKX1.” Database Genecore on STN, AN X85545. Institute of Human Genetics. Jun. 5, 1997.
Klink et al. “The Human Protein Kinase Gene PKX1 on Xp22.3 Displays Xp/Yp Homology and is a Site of Chromosomal Instability.” Database Genecore on STN, AN P51817. Human Mol. Genet. 1995, 4:869-878.
Li et al. “PRKX, A Phylogenetically and Functionally Distinct cAMP-Dependant Protein Kinase, Activities Renal Epithelial Cell Migration and Morphogenesis.” Proc Natl Acad Sci USA. Jul. 9, 2002, vol. 99, No. 14, pp. 9260-9265.
Ausubel et al. “Short Protocols in Molecular Biology.” 3rdEdition, Wiley & Sons Inc. 1995.
International Search report dated Nov. 6, 2003.
Results of BLAST Search of SEQ ID No:2 against Derwent (FastAlertP and GENESEQP) and NCBI (pataa) protein patent databases on Sep. 8, 2004 (13 pages).

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