Isolated human inositol polyphosphate 5-phosphatase

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase

Reexamination Certificate

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C435S196000, C435S320100, C435S069100, C536S023200, C530S350000, C424S094600

Reexamination Certificate

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06908743

ABSTRACT:
Reagents which regulate human inositol polyphosphate 5-phosphatase and reagents which bind to human inositol polyphosphate 5-phosphatase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, COPD, asthma, diabetes, and cancer.

REFERENCES:
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Database Swall “Online” Nov. 1, 1996 “Phosphatidylinositol (4, 5) biphosphate 5-phosphatase homolog (Fragment)” Database accession No. Q15735.
Database EMBL “Online” Jul. 8, 1996 “Human phosphatidylinositol (4,5) biphosphate 5-phosphatase homolog mRNA; partial cds” Database accession No. U45975.
Mochizuki Yasuhiro et al: “Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles.” Journal of Biological Chemistry, vol. 274, No. 51, Dec. 17, 1999, pp. 36790-36795.
Mochizuki et al., “Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles,” J Biol chem. 275, pp. 20956 (2000) Erratum.
Database Swall “ONLINE” Oct. 1, 2000 “Proline-rich inositol polyphosphate 5-phosphatase” Database accession No. Q9JMC1.
Database EMBL “Online” Feb. 6, 2000 “Rattus norvegicus PIPP mRNA for proline-rich inositol polyphosphate 5-phosphatase, complete cds” Database accession No. AB032551.
Database Swall “Online” May 1, 2000 “WUGSC:H_DJ412A9.2 protein” Database accession No. 09UDT9.
Database EMBL “Online” Jun. 15, 1998 “Homo sapiensPAC clone RP3-412A9 from 22, complete sequence” Database accession No. AC005005.
Erneux C et al: “The diversity and possible functions of the inositol polyphosphate 5-phosphatases” Biochimica et Biophysica Acta, vol. 1436, No. 1-2, pp. 185-199, Dec. 8, 1998.
Kudo et al., “Localization of mRNA and SHIP2, SH2 domain-containing inositol polyphosphate 5-phosphatase in the brain of developing and mature rats,” Brain Res Mol Brain Res 75, pp 172-177 (2000).
Safrany et al., “Design of potent and selective inhibitors of myo-inositol 1,4,5-trisphosphate 5-phosphatase,” Biochemistry 33, pp. 10763-10769 (1994).
Speed et al., “Tissue distribution and intracellular localization of the 75-kDa inositol polyphosphate 5-phosphatase,” Eur J Biochem 234, pp. 216-224, 1995.

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