Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Patent
1995-06-05
1999-03-16
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
435 691, 435 697, 4352523, 4353201, 536 232, 935 14, 935 29, 935 72, C12N 902, C12N 1553, C12N 1570
Patent
active
058829083
ABSTRACT:
A human tissue inducible nitric oxide synthase cDNA clone is disclosed. A process for preparing this cDNA clone coding for human tissue inducible nitric oxide synthase and for expressing the human tissue inducible nitric oxide synthase protein are provided.
REFERENCES:
patent: 4652639 (1987-03-01), Stabinsky
patent: 5132407 (1992-07-01), Stuehr et al.
patent: 5268465 (1993-12-01), Bvedt et al.
patent: 5468630 (1995-11-01), Billiur et al.
Nussler, et al., 1992; Inducible Human Hepatocyte Nitric Oxide Synthase: ning of the Gene and its Regulation by Cytokines and LPS; J. Leukocyte Biology; Supplement 3, 1992, 29th National Meeting, Society for Leukocyte Biology, Dec. 2-5 1992.
Nussler, et al., 1992, FASEB Meeting; Anaheim, CA; Stimulation of Nitric Oxide in Hepatocytes by Cytokines; Abst. 5200.
Lowenstein, et al; Aug. 1992; Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme; Proc. Natl. Acad. Sci, USA; vol. 89, pp. 6711-6715.
Bredt, et al; 1991; Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase; Nature; vol. 351. pp. 714-718.
Kie, et al; 1992; Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages; Science; vol. 256, pp. 225-228.
Marsden, et al; 1992; Molecular cloning and characterization of human endothelial nitric oxide; Elsevier Science publishers B.V.; vol. 307, pp. 287-293.
Palmer, et al; 1987; Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor; Nature 327: 524-526.
Ignarro, et al; 1987; Endothelium-derived relaxing factor produced and released from artery and vein in nitric oxide; Proc. Natl. Acad. Sci. USA. 84: 9265-9269.
Bredt and Snyder; 1989; Nitric Oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum; Proc. Natl. Acad. Sci. USA, 86: 9030-9033.
Burnett, et al; 1992; Nitric Oxide: A Physiologic Mediator of Penile Erection; Science; 257: 401-403.
Granger, et al; 1987; Specific Amino Acid (L-Arginine) Requirement for the Microbiostatic Activity of Murine Macrophages; J. Clin. Invest. 81: 1129-1136.
Hibbs, Jr., et al; 1987; Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite; 235: 473-476.
Busse and Mulsch; 1990; Calcium-dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin; FEBS Letters 265: 133-136.
Kilbourn, et al; 1990; N.sup.6 -Methyl-Larginine inhibits tumor necrosis factor-induced hypotension: Implications for the involvement of nitric oxide; Proc. Natl. Acad. Sci. USA; vol. 87: 3629-3632.
Mulligan, et al; 1992; Lung Injury After Deposition of IgA Immune Complexes; J. Immunology; 148: 3086-3092.
Corbett, et al; 1991; Interleukin-1.beta.-induced Formation of EPR-detectable Iron-Nitrosyl Complexes in Islets of Langerhans; J. Biol. Chem. 266: 21351-21354.
Summers and Smith, 1988, A Manual of Methods For Baculovirus Vectors and Insert Cell Culture Procedures; Texas Agricultviral Experiment Station Bulletin No. 1555.
Curran, et al; 1991; Nitric oxide and nitric oxide-generating compounds inhibit hepatocyte protein synthesis; FEBS Letters 5: 2085-2092.
Billiar, et al., 1992, Association Between Synthesis and Release of CGMP and Nitric Oxide Biosynthesis by Hepatocytes, Amer. Physiol. Soc., C1077-C1082.
Drapier, J.C., 1991, Res.Immoc. 39th Forum In Immunol; See specifically pp. 557, 562 and 589-590.
Bredt and Snyder, 1990, Isolation of Nitric Oxide Synthetase, a Calmodulin-Requiring Enzyme Proc. Natl. Acad. Sci., 87: 682-685.
Billiar, et al., 1991, Cytokine-Induced Synthesis and Release of cGMP by Hepatocytes is Mediated by Nitric Oxide, FASEB Journ. 5 (5): A1344, Ab. No. 5642.
Knowles, et al., 1990, Anti-Inflammatory Glucocorticoids Inhibit the Induction by Endotoxin of Nitric Oxide Synthase in the Lung, Liver, and Aorta of the Rat, Biochem. and Biophys. Resch.
Commun., 172 (3): 1042-1048.
Stadler, et al., 1991, Effect of Endogenous Nitric Oxide on Mitochondrial Respiration of Rat Hepatocytes In Vitro and In Vivo, Arch. Surg., vol. 126 (2): 186-191.
Nathan, 1991, A Commentary: Inducible Nitric Oxide Synthase, Research Immunol. 142 (7): 600-602.
Wright, et al., 1992, Protective and Pathological Roles of Nitric Oxide in Endotoxin Shock, Cardiovascular Resch., 26 (1): 48-57.
Di Silvio, et al., 1992, Impairment of Nitric Oxide Synthesis by Hepatocytes from Chronic Ethanol Treated Animals, Gastroenterology 102: A801.
Klatt, et al., 1992, Ca .sup.2+ /Calmodulin-Dependent Cytochrome C Reductase Activity of Brain Nitric Oxide Synthase, J. Biol. Chem. 267(16): 11374-11378.
Harbrecht, et al., 1992, Inhibition of Nitric Oxide Synthesis During Endotoxemia Promotes Intrahepatic Thrombosis and an Oxygen Radical-Mediated Hepatic Injury, Journ. of Leukocyte Biology, 52 (4): 390-394.
Harbrecht, et al., 1992, Nitric Oxide Synthesis Serves to Reduce Hepatic Damage During Acute Murine Endotoxemia, Critical Care Medicine, 20 (11): 1568-1574.
Fortkamp, et al., 1986, Cloning and Expression in Escherichia Coli of a Synthetic DNA for Hirudin, the Blood Coagulation Inhibitor in the Leech, DNA 5: 511-517.
Oguchi, et al., 1992, Induction of Ca.sup.2+ /Calmodulin-Dependent NO Synthase in Various Organs of Rats by Propionibacterium Acnes and Lipopolysaccharide Treatment, FEBS Letters 308 (1): 22-25.
Hevel, et al., 1991, Purification of the Inducible Murine Macrophage Nitric Oxide Synthase, J. Biol. Chem. 266(34): 22789-22791.
Hibbs, et al., 1992, Evidence for Cytokine-Inducible Nitric Oxide Synthesis from L-Arginine in Patients Receiving Interleukin-2 Therapy, J. Clin. Invest. 89: 867-877.
Billiar, et al., 1991, Two Unique Aspects of Inducible .N=0 Synthase in Liver Cells and Accessory Cells: Hepatic Damage is Minimized by Hepatocyte .N=0 Production and Immunoregulation is Mediated by Macrophase .N=0 Production, Resch. in Immunol. 142: 584-586.
Oshima, et al., 1992, Purificationi of Nitric Oxide Syntheses from Bovine Brain: Immunological Characterization and Tissue Distribution, Biochem. and Biophys. Resch. Commun., vol. 183 (1): 238-244.
Denis, 1991, Tumor Necrosis Factor and Granulocyte Macrophage-Colony Stimulating Factor Stimulate Human Macrophages to Restrict Growth of Virulent Mycobacterium Avium and to Kill Avirulent M. Avium: Killing Effector Mechanism Depends on the Generation of Reactive Nitrogen Intermediates, Journ. of Leukocyte Biol., vol. 49: 380-387.
Hunt and Goldin, 1992, Nitric Oxide Production by Monocytes in Alcholic Liver Dusease, Journ. of Hepatology, vol. 14: 146-150.
Munoz-Fernandez, et al., 1992, Activation of Human Macrophages for the Killing of Intracellular Trypanosoma Cruzi by TNF-.gamma. and IFN-.gamma. Through a Nitric Oxide-Dependent Mechanism, Immunol. Ltrs., 33: 35-40.
Cameron, et al., 1990, Human Alveolar and Peritoneal Macrophages Mediate Fungistasis Independently of L-Arginine Oxidation to Nitrite or Nitrate, Amer. Review of Respiratory Disease, 142: 1313-1319.
Sherman, et al., 1991, Cytokine-and Pneumocystis Carinii-Induced L-Arginine Oxidation by Murine and Human Pulmonary Alveolar Macrophages, J. Protozool., 38 (6): 234S-236S.
James, et al., 1990, Activation of Human Monocyte-Derived Macrophages to Kill Schistosomula of Schistosoma Mansoni In Vitro, J. Immunol. 145 (8): 2686-2690.
Padgett and Pruett, 1992, Evaluation of Nitrite Production by Human Monocyte-Derived Macrophages, Biochem. and Biophys. Resch. Commun., vol. 186 (2): 775-781.
Dawson, et al., 1991, Nitric Oxide Synthase and Neuronal NADPH Diaphorase are Identical in Brain and Peripheral Tissues, Proc. Natl. Acad. Sci., vol. 88: 7797-7801.
Billiar, et al., 1990, Inducible Cytosolic Enzyme Activity for the Production of Nitrogen Oxides from L-Arginine in Hepatocytes, Biochem. and Biophys. Resch. Commun. vol. 168 (3): 1034-1040.
Billiar, et al., 1989, An L-Arginine-Dependent Mechanism Mediates Kupffer Cell Inhibition of Hepatocyte Protein Synthesis In Vitro, J. Exp. Med. 169: 1467-1472.
Ochoa, et al., 1991, Nitrogen Oxide Levels in Patients After Trauma and During Sepsis, Ann. Surg. 621-626.
Curran, et al., 1990, Multiple Cytokines are Required to Induce Hep
Billiar Timothy R..
Geller David A.
Nussler Andreas K.
Simmons Richard L.
Moore William W.
University of Pittsburgh of the Commonwealth System of Higher Ed
Wax Robert A.
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