Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-07-04
2006-07-04
Murphy, Joseph (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Reexamination Certificate
active
07071305
ABSTRACT:
This invention is concerned with human organic anion transporter (“hOAT”). Isolated nucleic acid encoding hOAT is provided, along with ioslated hOAT polypeptide. hOAT nucleic acid and/or hOAT polypeptide are employed in transgenic animals, recombinant cells, replicable vectors and analytical procedures for identifying hOAT agonists or antagonists, assays for identifying hOAT alleles and/or isotypes, screening tests for nephrotoxic or neurologically active compounds, and determination of drug-drug interactions within the kidney or brain.
REFERENCES:
patent: WO 97/31111 (1997-08-01), None
patent: WO 97/42321 (1997-11-01), None
patent: WO 98/53064 (1998-11-01), None
Pettit GR et al. Antineoplastic agents. 400. Synthesis of the Indian Ocean marine sponge cyclic heptapeptide phakellistatin 2. Nat Prod. Mar. 1999;62(3):409-14.
Sekine T et al.,Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem. 1997 Ju 25;272(30):18526-9.
Voet et al. Biochemistry. 1990. John Wiley & Sons, Inc. pp. 126-128 and 228-234.
Mickle JE et al. Genotype-phenotype relationships in cystic fibrosis. Med Clin North Am. May 2000;84(3):597-607.
Reid G et al. Cloning of a human renal p-aminohippurate transporter, hROAT1. Kidney Blood Press Res. 1998;21(2-4):233-7.
Apiwattanakul et al., “Transport Properties of Nonsteroidal Anti-Inflammatory Drugs by Organic Anion Transporter 1 Expressed in Xenopus laevis Oocytes”, 55:847-854, Mol Pharm, 1999.
Cihlar et al., “The Antiviral Nucleotide Analogs Cidofovir and Adefovir Are Novel Substrates for Human and Rat Renal Organic Anion Transporter 1”, 56:570-580, Molecular Pharmacology, 1999.
Cundy et al., “Effect of Probenecid on the Distribution, Metabolism, and Excretion of Cidofovir in Rabbits”, 24(3):315-321, The American Society for Pharmacology and Experimental Therapeutics, 1996.
Fisher et al., “Safety of adefovir dipivoxil (ADV) and Incidence of Proximal Renal Tubular Disorder (PRTD) in a Placebo (PLC)-Controlled Trial in Patients (Pt) with Advanced HIV Disease”, Abstract 678, 6th Conference on Retroviruses and Opportunistic Infections, Chicago, IL, Jan. 31-Feb. 4, 1999.
Hosoyamada et al., “Molecular Cloning and functional Expression of a Multispecific Organic Anion Transporter from Human Kidney”, 45(1):F122-F128, Am J Physiol, Jan. 1999.
Kuze et al., “Heterologous Expression and Functional Characterization of a Mouse Renal Organic Anion Transporter in Mammalian Cells”, 274(3):1519-1524, J Biol Chem, 1999.
Lalezari et al., “Intravenous Cidofovir for Peripheral Cytomegalovirus Retinitis in Patients with AIDS”, 126(4):257-263, Ann Int Med, Feb. 15, 1997.
Lopez-Nieto et al., “Molecular Cloning and Characterization of NKT , a Gene Product Related to the Organic Cation Transporter Family that is Almost Exclusively Expressed in the Kidney”, 272(10):6471-6478, J Biol Chem, Mar. 7, 1997.
Lu et al., “Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C”, 45(2):F295-F303, Am J Physiol, Feb. 1999.
Lu et al., “Cloning of a Human Kidney P-aminohippurate (PAH) Transporter: Narrow Substrate Specificity and Regulation by Protein Kinase C”, 9:54A XP002097951, Journal of the American Society of Nephrology, Sep. 9, 1998.
Mulato et al., “Nonsteroidal Anti-Inflammatory Drugs Efficiently Reduce the Transport and Cytotoxicity of Adefovir Mediated by the Human Renal Organic Anion Transporter 1”, 295(1):10-15, The Journal of Pharmacology and Experimental Therapeutics, Mar. 14, 2000.
Race et al., “Molecular Cloning and Characterization of Two Novel Human Renal Organic Anion Transporters (hOAT1 and hOAT3)”, 255:508-514, Biochem Biophys Res Comm, 1999.
Reid et al., “Cloning of a Human Renal p-Aminohippurate Transporter, hROAT1”, 21:233-237, Kidney & Blood Pressure Research, 1998.
Rudinger, J., “Peptide Hormones”, pp. 1-7, University Park Press, Baltimore, (J. A. Parsons, ed.), 1976.
Saito et al., “Cloning and Functional Characterization of a Novel Rat Organic Anion Transporter Mediating Basolateral Uptake of Methotrexate in the Kidney”, 271(34):20719-20725, J Biol Chem, Aug. 23, 1996.
Sekine et al., “Expression Cloning and Characterization of a Novel Multispecific Organic Anion Transporter”, 272(30):18526-18529, J Biol Chem, Jul. 25, 1997.
Sweet et al., “Expression Cloning and Characterization of ROAT1”, 272(48):30088-30095, J Biol Chem, Nov. 28, 1997.
Tune, B.M., “Nephrotoxicity of beta-lactam antibiotics: mechanisms and strategies for prevention”, 11:768-772, Pediatr. Nephrol., 1997.
Wolff et al., “Expression Cloning and Characterization of a Renal Organic Anion Transporter from Winter Flounder”, 417(3):287-291, FEBS, 1997.
Bosse Mark L.
Gilead Sciences, Inc.
Murphy Joseph
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