Isolated Herpesvirus saimiri proteins that bind MHC Class II mol

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

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4241921, 4242291, 4242311, 530350, 530226, 435693, 435697, A61K 3912, A61K 3900, A61K 39245, C07K 100, C07C24500

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active

057166234

ABSTRACT:
Isolated viral proteins, and compositions made therefrom, are disclosed which are capable of binding to Class II Major Histocompatibility Complex antigen, thereby functioning to inhibit an antigen-specific response. The isolated viral proteins also act as superantigens.

REFERENCES:
Kotzin et al., Advances in Immunology, vol. 54, pp. 99-166; 1993.
Albrecht et al., J. Virol. 66:5047; 1992.
Nicholas et al., Virol. 179:189; 1990.
Thompson and Nicholas, Nature 351:530;1991.
Choi et al., Nature 350:203; 1991.
Albrecht et al., Virol. 174:533; 1990.
Sambrook et al., "The Effects of Length and Degeneracy of the Oligonucleotide on the Specificity of Hybridization," In: Molecular Cloning, A Laboratory Manuel, Second Edition, Cold Spring Harbor Laboratory Press, pp. 11.7-11.8, 1989.
Kotzin et al., "Superantigens and Their Potential Role in Human Diseases," Adv. Immunol. 54: 99-166 (1993).

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