Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-09-02
2000-10-03
Walsh, Donald P.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C07H 1700
Patent
active
H00019038
ABSTRACT:
The present invention relates to an isolated human hair specific keratin gene or fragment thereof, comprising a DNA sequence selected from the group consisting of SEQ ID NO:11; and a DNA sequence comprising DNA sequences SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9 and SEQ ID NO:10. The present invention also relates to a method for detecting the level of hair specific keratin in a biological sample. The present invention further relates to a method of identifying hair growth regulating compounds and compositions comprising: a) treating a subject with a compound or composition of interest; b) isolating a sample of hair from the subject; and c) using a DNA sequence, or fragment thereof, which encodes hair specific keratin as a marker in a biological assay to detect an increase in the production of hair specific keratin in the hair sample.
Bowden Paul Edward
Luo Xiaochun
Wawrzyniak Cynthia Jo.
Chi Anthony R.
Corstanje Brahm J.
Rasser Jacobus C.
Suter David L.
The Procter & Gamble & Company
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