Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2005-01-18
2005-01-18
Ulm, John (Department: 1646)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S007200, C435S007210, C435S483000
Reexamination Certificate
active
06844193
ABSTRACT:
Disclosed herein are compositions and methods which are useful in the identification and isolation of components involved in transmembrane receptor-mediated signaling. Such components include the receptors themselves (e.g., tyrosine kinase receptors, cytokine receptors and tyrosine phosphatase receptors), as well as ligands which bind the receptors and modulators of the downstream intracellular catalytic event which characterizes receptor-mediated signalling. Two novel ligands for the FGF receptor and the nucleotide sequences encoding them are also described.
REFERENCES:
patent: 5238916 (1993-08-01), Goldfarb et al.
patent: 5256643 (1993-10-01), Persico et al.
patent: 5264557 (1993-11-01), Salomon et al.
patent: 2223495 (1990-04-01), None
patent: 04036184 (1992-02-01), None
patent: 8904832 (1989-06-01), None
patent: 9213948 (1992-08-01), None
patent: 9319096 (1993-09-01), None
patent: 9413796 (1994-06-01), None
Miki et al. Expression cDNA Cloning of the KGF Receptor by Creation of a Transforming Autocrine Loop. 04 Jan. 1991. Science 251:72-75.*
Sachpatzidis et al. Identification of Allosteric Peptide Agonists of CXCR4*. 10 Jan. 2003. J. Biol. Chem. 278(2):896-907.*
Hanks, S. K., “Eukaryotic Protein Kinases,”Current Opinion in Structural Biology, 1:369-383 (1991).
Fett, J. W., et al., “Isolation and Characterization of Angiogenin, an Angiogenic Protein from Human Carcinoma Cells,”Biochemistry, 24(20):5480-5486 (1985).
Maes, P., et al., “The Complete Amino Acid Sequence of Bovine Milk Angiogenin,”FEBS Letters, 241(1,2):41-45 (1988).
Wilson, R., et al., “2.2 Mb of Contiguous Nucleotide Sequence from Chromosome III ofC. elegans,” Nature, 368:32-38 (1994).
Hao, Q. L., et al., “Isolation and Sequence Analysis of a Novel Human Tyrosine Kinsase Gene,”Molecular and Cellular Biology, 9(4):1587-1593 (1989).
Johnson, D. E., et al., “Diverse Forms of a Receptor for Acidic and Basic Fibroblast Growth Factors,”Molecular and Cellular Biology, 10:4728-4736 (1990).
Haugg and Schein, “The DNA Sequences of the Human and Hamster Scretory Ribonucleases Determined with the Polymerase Chain Reaction (PCR),”Nucleic Acids Research, 20(3):612 (1992).
Ciccodicola, A., et al., “Molecular Characterization of a Gene of the ‘EGF Family’ Expressed in Undifferentiated Human NTERA2 Teratocarcinoma Cells,”The EMBO Journal, 8(7):1987-1991 (1989).
Dono, R., et al., “The MurineCriptoGene: Expression During Mesoderm Induction and Early Heart Morphogenesis,”Development, 118:1157-1168 (1993).
Basilico and Moscatelli, “The FGF Family of Growth Factors and Oncogenes,”Adv. Cancer Res., 59:115-165 (1992).
Cheng and Flanagan, “Identification and Cloning of ELF-1, a Developmentally Expressed Ligand for the Mek 4 and Sek Receptor Tyrosine Kinases,”Cell, 79:157-168 (1994).
Flanagan and Leder, “The kit Ligand: A Cell Surface Molecule Altered in Steel Mutant Fibroblasts,”Cell, 63:185-194 (1990).
Carlson, M., et al., “The Secreted Form of Invertase inSaccharomyces cerevisiaeIs Synthesized from mRNA Encoding a Signal Sequence,”Molecular and Cellular Biology, 3(3):439-447 (1983).
Musci, T. J., et al., “Regulation of the Fibroblast Growth Factor Receptor in EarlyXenopusEmbryos,”Proc. Natl. Acad Sci. USA, 87:8365-8369 (1990).
Elledge, S. J., et al., “λYES: A Multifunctional cDNA Expression Vector for the Isolation of Genes by Complementation of Yeast andEscherichia coliMutations,”Proc. Natl. Acad. Sci. USA, 88:1731-1735 (1991).
Kornbluth, S. et al., “Novel Tyrosine Kinase Identified by Phosphotyrosine Antibody Screening of cDNA Libraries,”Molecular and Cellular Biology, 8(12):5541-5544, (1988).
Amaya, E., et al., “Expression of a Dominant Negative Mutant of the FGF Receptor Disrupts Mesoderm Formation in Xenopus Embryos,”Cell, 66:257-270 (1991).
Gallwitz, D., et al., “The Actin Gene in Yeast Saccharomyces Cerevisiae: 5′ and 3′ End Mapping, Flanking and Putative Regulatory Sequences,”Nucleic Acids Research, 9:6339-6350 (1981).
Kimelman, D., et al., “The Presence of Fibroblast Growth Factor in the Frog Egg: Its Role as a Natural Mesoderm Inducer,”Science, 242:1053-1056 (1988).
Isaacs, H.V., et al., “Expression of a Novel FGF in theXenopusEmbryo. A New Candidate Inducing Factor for Mesoderm Formation and Anteroposterior Specification,”Development, 114:711-720 (1992).
Tannahill, D., et al., “Developmental Expression of theXenopus int-2(FGF-3) Gene: Activation by Mesodermal and Neural Induction,”Development, 115:695-702 (1992).
Joseph, L. J., et al., “Complete Nucleotide and Deduced Amino Acid Sequences of Human and Murine Preprocathepsin L. An Abundant Transcript Induced by Transformation of Fibroblasts,”J. Clin. Invest., 81:1621-1629 (1988).
Gal and Gottesman, “Isolation and Sequence of a cDNA for Human Pro-(Cathepsin L),”Biochem. J., 253:303-306 (1988).
Kay, B. K., et al., “Potential for Two Isoforms of the Al Ribonucleoprotein inXenopus laevis,” Proc. Natl. Acad. Sci. USA, 87:1367-1371 (1990).
Kim and Baker, “Isolation of RRM-Type RNA-Binding Protein Genes and the Analysis of Their Relatedness by Using a Numerical Approach,”Molecular and Cellular Biology, 13(1):174-183 (1993).
Nieuwkoop and Faber (editors), “The Further Development of the Intestinal Tract and Glands,” “External and Internal Stage Criteria in the Development ofXenopus Laevis,” Normal Table of Xenopus Laevis (Daudin),pp. 160-170, North-Holland Publishing Company, Amsterdam (1956).
Lyons and Nelson, “An Immunological Method for Detecting Gene Expression in Yeast Colonies,”Proc. Natl. Acad. Sci USA, 81:7426-7430 (1984).
Kinoshita Noriyuki
Kirschner Marc W.
Hamilton Brook Smith & Reynolds P.C.
President and Fellows of Harvard College
Ulm John
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