Isolated domains of type IV collagen to modify cell and tissue i

Details Isolated domains of type IV collagen to modify cell and tissue i Isolated domains of type IV collagen to modify cell and tissue i

1997-02-18

1999-01-05

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435325, 435375, 530356, C12N 500

Patent

active

058561846

ABSTRACT:
The instant invention demonstrates that the 7S domain of type IV collagen disrupts cell aggregation and tissue development. Structural changes in mesoglea, inhibition of cell proliferation, and changes in cell differentiation patterns accompanies the blockage of cell aggregates which indicate that blockage may be due to alterations in mesoglea (extracellular matrix) structure with accompanying effects on cell behavior. Type IV collagen has a critical role in the initial formation of mesoglea and that perturbation of mesoglea formation affects cell division, cell differentiation, and morphogenesis.

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