Isolated DNA sequence for a novel macrophage receptor with a col

Details Isolated DNA sequence for a novel macrophage receptor with a col Isolated DNA sequence for a novel macrophage receptor with a col

1995-02-21

1997-11-25

Allen, Marianne P.

Chemistry: molecular biology and microbiology

Vector, per se

536 235, 935 11, C12N 1585, C12N 1512

Patent

active

056911971

ABSTRACT:
The present invention is directed to processes for isolating and identifying the nucleotide sequence of a gene for a novel macrophage receptor with collagenous structure, termed "MARCO". The new macrophage receptor with a collagenous domain binds gram positive and negative bacteria and acetylated LDL. Moreover, the invention relates to the nucleotide sequence for MARCO identified by the process of the invention and the isolated and purified polypeptide chain encoded by such a sequence.

REFERENCES:
Ashkenas et al. J. of Lipid Research 34 (1993) 983-1000.
Krieger and Herz. Am. Rev. Biochem 63 (1994) 601-637.

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