Isolated DNA molecules for integration site independent gene exp

Details Isolated DNA molecules for integration site independent gene exp Isolated DNA molecules for integration site independent gene exp

1995-06-07

1998-04-07

Rories, Charles C.P.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 696, 435 701, 435 703, 435 704, 4353201, 4352402, 4351723, 435 6, 536 241, 800 2, C12N 510, C12N 1563, C12N 1567, C12N 1585

Patent

active

057363595

ABSTRACT:
Vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant activator sequence capable of eliciting host cell-type restricted, integration site independent, copy number dependent expression of the gene.

REFERENCES:
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Kollias et al., "Regulated Expression of Human .sup.A .gamma., .beta.-, and Hybrid .gamma..beta.-Globin Genes in Transgenic Mice: Manipulation of the Developmental Expression Patterns", Cell, vol. 46, pp. 89-94, (Jul. 04, 1986).
Lang et al., "The structure of the human CD2 gene and its expression in transgenic mice", The EMBO Journal, vol. 7, No. 6, pp. 1675-1682, (Jun., 1988).
Li et al., "Nucleotide Sequence of 16-Kilobase Pairs of DNA 5' to the Human .epsilon.-Globin Gene", The Journal of Biology an Chemistry, pp. 14901-14910, (1985).
Magram et al., "Developmental regulation of a cloned adult .beta.-globin gene in transgenic mice", Nature, vol. 315, pp. 338-340, (May, 1995).
Marks et al., "Erythroleukemic Differentiation", Ann. Rev. Biochem., vol. 47, pp. 419-448, (1978).
Tuan et al., "The .beta.-like-globin" gene domain in human erythroid cells, Proc. Natl. Acad. Sci. USA, vol. 82, pp. 6384-6388, (Oct., 1985).

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