Chemistry: molecular biology and microbiology – Vector – per se
Patent
1993-12-02
1995-11-21
Wax, Robert A.
Chemistry: molecular biology and microbiology
Vector, per se
435 711, 435 713, 424 932, 530350, 530825, 536 221, 536 231, 536 237, C12N 1500, C07H 1900, C07H 2100, C12P 2104
Patent
active
054686393
ABSTRACT:
Substantially pure enterotoxins of Shigella flexneri 2a are described, along with a method for obtaining the same, antibodies having binding specificity to the enterotoxins and a method for use of the enterotoxins to develop a non-reactogenic Shigella flexneri 2a vaccine candidate.
REFERENCES:
patent: 5204097 (1993-04-01), Arnon et al.
Glover, "Principles of Cloning DNA", Gene Cloning pp. 1-20 1984.
Lee et al. "Generation of cDNA Probes . . . " Science vol. 239, pp. 1288-1291 Mar. 11, 1988.
Fasano et al, J. Pediatr. Gastroenterol. Nutr., 13:320 (1991).
Fasano et al, Infect. Immun., 58(11):3717-3723 (1990).
Maurer et al, Methods in Enzymology, 70:49-70 (1980).
Strockbine et al, Infect. Immun., 50(3):695-700 (1985).
Levine, J. Inf. Dis., 155(3):377-389 (1987).
Fasano et al, "Elaboration of an Enterotoxin by Shigella Flexneria 2a", Rivista Italian Di Pediatria, 17(4):182 (Abstract) (Aug., 1991).
Lecture Slides, "Production by Enteroinvasive E. coli and Shigella Flexneria 2a of a Novel Enterotoxin Moiety", presented at Walter Reed Army Institute, Apr. 15, 1990.
Fasano et al, "Enterotoxic Factors Elaborated by Shigella Flexneria 2a", presented at the 29th U.S.-Japan Joint conference on Cholers and Related Diarrheal Diseases, Dec. 2, 1992.
Nataro et al, "Cloning and Sequencing of a New Plasmid-Encoded Enterotoxin in Enteroinvasive E. coli and Shigella", presented at the 29th U.S.-Japan Joint Conference on Cholers and Related Diarrheal Diseases, Dec. 2, 1992.
Noriega et al, "Construction and Characterization of Oral Attenuated Shigella Vaccine-Candidates and their Potential Use as Live Vector-Hyrbrid Vaccines", presented at the 29th U.S.-Japan Joint Conference on Cholera and Related Diarrheal Diseases, Dec. 2, 1992.
Fasano Alessio
Levine Myron M.
Nataro James P.
Noriega Fernando
Kim Hyosuk
University of Maryland at Baltimore
Wax Robert A.
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