Isolated DNA molecule encoding ShET2 of Shigella flexneri 2a

Chemistry: molecular biology and microbiology – Vector – per se

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435 711, 435 713, 424 932, 530350, 530825, 536 221, 536 231, 536 237, C12N 1500, C07H 1900, C07H 2100, C12P 2104

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active

054686393

ABSTRACT:
Substantially pure enterotoxins of Shigella flexneri 2a are described, along with a method for obtaining the same, antibodies having binding specificity to the enterotoxins and a method for use of the enterotoxins to develop a non-reactogenic Shigella flexneri 2a vaccine candidate.

REFERENCES:
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Levine, J. Inf. Dis., 155(3):377-389 (1987).
Fasano et al, "Elaboration of an Enterotoxin by Shigella Flexneria 2a", Rivista Italian Di Pediatria, 17(4):182 (Abstract) (Aug., 1991).
Lecture Slides, "Production by Enteroinvasive E. coli and Shigella Flexneria 2a of a Novel Enterotoxin Moiety", presented at Walter Reed Army Institute, Apr. 15, 1990.
Fasano et al, "Enterotoxic Factors Elaborated by Shigella Flexneria 2a", presented at the 29th U.S.-Japan Joint conference on Cholers and Related Diarrheal Diseases, Dec. 2, 1992.
Nataro et al, "Cloning and Sequencing of a New Plasmid-Encoded Enterotoxin in Enteroinvasive E. coli and Shigella", presented at the 29th U.S.-Japan Joint Conference on Cholers and Related Diarrheal Diseases, Dec. 2, 1992.
Noriega et al, "Construction and Characterization of Oral Attenuated Shigella Vaccine-Candidates and their Potential Use as Live Vector-Hyrbrid Vaccines", presented at the 29th U.S.-Japan Joint Conference on Cholera and Related Diarrheal Diseases, Dec. 2, 1992.

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