Isolated DNA molecule encoding SHET1 of Shigella flexneri 2a and

Details Isolated DNA molecule encoding SHET1 of Shigella flexneri 2a and Isolated DNA molecule encoding SHET1 of Shigella flexneri 2a and

1994-11-30

1996-12-31

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 711, 435 713, 4352521, 4353201, 530350, 530825, 536 221, 536 231, 536 237, C12N 120, C12P 2104, C07K 100, C07H 1900

Patent

active

055893805

ABSTRACT:
Substantially pure enterotoxins of Shigella flexneri 2a are described, along with a method for obtaining the same, antibodies having binding specificity to the enterotoxins and a method for use of the enterotoxins to develop a non-reactogenic Shigella flexneri 2a vaccine candidate.

REFERENCES:
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Fasano et al, "Enterotoxic Factors by Shigella Flexneria 2a", presented at the 29th U.S.-Japan Joint Conference on Cholera and Related Diarrheal Diseases, Dec. 2, 1992.
Nataro et al, "Cloning and Sequencing of a New Plasmid-Encoded Enterotoxin in Enteroinvasive E. coli and Shigella", presented at the 29th U.S.-Japan Joint Conference on Chlorera and Related Diarrheal Diseases, Dec. 2, 1992.
Noriega et al, "Construction and Characterization of Oral Attenuated Shigella Vaccine-Candidates and their Potential Use as Live Vector-Hyrbrid Vaccines", presented at the 29th U.S.-Joint Conferences on Cholera and Related Diarrheal Diseases, Dec. 2, 1992.
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