Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1994-06-02
1996-12-17
Walsh, Stephen G.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
435 691, 435 697, 4353201, 530350, 536 234, 536 235, C07K 14705, C07K 1900, C12N 1512, C12N 1562
Patent
active
055852696
ABSTRACT:
Isolated DNAs encoding a mammalian c-mer receptor which exhibits c-mer protooncogene activity and tyrosine kinase activity are disclosed. Also disclosed are vectors containing such DNAs, host cells containing such DNAs, c-mer receptor proteins, and soluble axl receptors, chimeric proteins including the extracellular domain of the c-mer receptor and DNAs encoding such chimeric proteins, and antibodies which specifically bind the c-mer receptor.
REFERENCES:
H. Earp, et al; Characterization of Distinct Tyrosine-specific Protein Kinases in B and T Lymphocytes, J. Biol. Chem. 260:4351-4356 (1985).
H. Earp, et al; Membranes from T and B Lymphocytes Have Different Patterns of Tyrosine Phosphorylation, Proc. Natl. Acad. Sci. USA 81:2347-2351 (1984).
J. O'Bryan et al; axl A Transforming Gene Isolated from Primary Human Myeloid Leukemia Cells, Encodes a Novel Receptor Tyrosine Kinase, Mol. Cell Biol. 11:5016-5031. (1991).
C. Lai & G. Lemke, An Extended Family of Protein-Tyrosine Kinase Genes Differentially Expressed in the Vertebrate Nervous System, Neuron 6:691-704 (1991).
D. K. Graham et al; Cloning and mRNA Expression Analysis of a Novel Human Protooncogene, c-mer, Cell Growth & Differentiation 5:647-657 (1994).
Dawson Thomas L.
Earp, III H. Shelton
Graham Doug
Mullaney David L.
Snodgrass Hiram R.
The University of North Carolina at Chapel Hill
Ulm John D.
Walsh Stephen G.
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