Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1991-12-31
1995-07-25
Draper, Garnette D.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
435 691, 4353201, 530350, 536 235, 536 2431, C07K 1471, C12N 1512
Patent
active
054361559
ABSTRACT:
The invention relates generally to compositions of and methods for obtaining somatostatin receptors. The invention relates as well to the DNA sequences encoding somatostatin receptors, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant somatostatin receptor polypeptides. By way of example, the invention discloses the cloning and functional expression of at least three different somatostatin receptors, SSTR1, SSTR2 and SSTR3 from two different mammalian sources. The invention includes as well, methods for using the isolated, recombinant receptor polypeptides in assays designed to select and improve substances capable of interacting with somatostatin receptor polypeptides for use in diagnostic, drug design and therapeutic applications.
REFERENCES:
patent: 4859609 (1989-08-01), Dull et al.
J. Biol. Chem. 264:18789-95 (Nov. 1989) Reyl-Desmars et al. Solubilization and Immunopurification of a Somatostatin Receptor from Human Gastric Tumoral Cell Line HGT-1*.
P.N.A.S. 83:599-603 (Feb. 1986) Ferretti et al. Total synthesis of a gene for bovine rhodopsin.
Meth. in Enzym. 91:399-413, (1983) Hunkapiller et al. High-Sensitivity Sequencing with a Gas-Phase Sequenator.
P.N.A.S. vol. 86; 1480-1484, Mar. 1989, He et al. Purification of a putative brain somatostatin receptor.
Nature vol. 311, 626-631, 18 Oct. 1984, Leonard et al. Molecular cloning and expression of cDNAs for human interleukin-2 receptor.
Nature vol. 313; 806-810, 28 Feb. 1985, Jacobs et al. Isolation and characterization of genome and cDNA clones of human erythropoietin.
Stephanie Rens-Domiano, et al; "Biochemical and Functional Properties of Somatostatin Receptors"; Journal of Neurochemistry, vol. 58, No. 6, pp. 1987-1996.
Meyerhof et al.,"Cloning of a cDNA Encoding a Novel Putative G-Protein-Coupled Receptor Expressed in Specific Rat Brain Regions," DNA and Cell Biology, vol. 10:689-694 (1991).
"Octreotide Steaming Ahead," The Lancet, vol. 339:837-839 (Apr. 4, 1992).
Bell Graeme I.
Seino Susumu
Yamada Yuichiro
ARCH Development Corporation
Draper Garnette D.
Ulm John D.
LandOfFree
Isolated DNA encoding a somatostatin receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Isolated DNA encoding a somatostatin receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated DNA encoding a somatostatin receptor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-739136