Isolated DNA encoding a novel human G-protein coupled receptor

Details Isolated DNA encoding a novel human G-protein coupled receptor Isolated DNA encoding a novel human G-protein coupled receptor

1997-04-17

1999-04-06

Degen, Nancy J.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 6, 4353201, 435366, 536 231, 536 235, C12N 1585, C12N 1563, C07H 2104, C12Q 168

Patent

active

058917209

ABSTRACT:
The present invention relates to the discovery, identification and characterization of nucleic acids that encode a novel G protein coupled receptor (I5E) protein. The invention encompasses I5E nucleotides, host cell expression systems, I5E proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an I5E transgene, or recombinant knock-out animals that do not express the I5E, antagonists and agonists of the receptor, and other compounds that modulate I5E gene expression or I5E activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or used to treat disorders such as inflammatory, central nervous system or gastrointestinal disorders.

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