Isolated dimeric fibroblast activation protein alpha, and uses t

Details Isolated dimeric fibroblast activation protein alpha, and uses t Isolated dimeric fibroblast activation protein alpha, and uses t

1996-03-18

1998-06-16

Allen, Marianne P.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 14475

Patent

active

057672423

ABSTRACT:
The invention involves dimeric forms of the protein known as fibroblast activation protein alpha, or "FAP.alpha." and its uses.

REFERENCES:
Rettig et al., "Fibroblast Activitation Protein: Purification, Epitope Mapping and Induction By Growth Factors", Int. J. Cancer 58: 385-392 (1994).
Rettig et al., "Regulation and Heterodimeric Structure of the Fibroblast Activation Protein in Normal and Transformed Cells of Mesenchymal and Neuroectodermal Origin", Can. Res. 53: 3327-3335 (Jul. 15, 1993).
Rettig et al., Cell Surface Glycoprotein of Human Sarcomas: Differential Expression in Normal and Malignant Tissues and Cultured Cells, Proc. Natl. Acad. Sci. USA 85: 3110-3114 (May 1988).
Aruffo et al., "Molecular Cloning of a CD28 cDNA by a High-efficiency COS Cell Expression System", Proc. Natl. Acad. Sci. USA 84: 8573-8577 (Dec. 1987).

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