Isolated cytolytic T cells which are specific for complexes OF H

Details Isolated cytolytic T cells which are specific for complexes OF H Isolated cytolytic T cells which are specific for complexes OF H

1998-04-14

1999-09-14

Chan, Christina Y.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435 724, 514 15, 514 16, C12N 1585, C07K 706

Patent

active

059522283

ABSTRACT:
The invention relates to isolated cytolytic T cells which recognize complexes of HLA-B35 molecules and the peptide defined by SEQ ID NO: 2, as well as methods for identifying HLA-B35 positive cells. The method involves contacting the cytolytic T cells to a sample, and determining activity of these cytolytic T cells.

REFERENCES:
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Fraser et al., "A License To Kill", Cell 85: 781-784 (Jun. 14,1996).
Boldin et al., Involvement of MACH, a Novel MORT 1/FADD-interacting Protease in Fas/APO-and TNF Receptor Induced Cell Death, Cell 85: 803-815 1996.
Muzio, et al., "FLICE, A Novel FADD-Homologous ICE/CED-3-like Protease Is Recruited To The CD95 (Fas/APO01) Death Inducing Signaling Complex", Cell 85: 817-827 (June 14, 1996).
Schonbach, et al., "Fine Tuning of Peptide Binding to HLA-B*3501 Molecules By Nonanchor Residues", J. Immunol. 154: 5951-5958 (1995).
Ramensee, et al., "MHC Ligands And Peptide Motifs: First Listing"Immunogentics 41: 178-228 (1995).
Seite et al., "Peptide Binding To The Most Frequent HLA-A Class I Alleles Measured By quantitative Molecular Binding Assays", Mol. Immunol. 31(11): 813-822 (1994).

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