Isolated cytolytic T cells specific for complexes of MAGE relate

Details Isolated cytolytic T cells specific for complexes of MAGE relate Isolated cytolytic T cells specific for complexes of MAGE relate

1995-05-17

1997-12-09

Caputa, Anthony C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435355, 4353723, 530328, C12N 506, C12N 508

Patent

active

056959940

ABSTRACT:
The invention involves a nonapeptide derived from the tumor rejection antigen precursor encoded by gene MAGE-3. This nonapeptide is presented by HLA molecules HLA-A1. The resulting complexes are identified by cytolytic T cells. Such recognition may be used in diagnostics, or therapeutically.

REFERENCES:
patent: 5342774 (1994-08-01), Boon et al.
patent: 5405940 (1995-04-01), Boon et al.
Rotzschke et al., "Isolated and analysis of naturally processed-Viral peptides as recognized by cytolytic T cells", Nature 348: 252-254 (1990).
Van der Bruggen et al., "A Gene Encoding An Antigen Recognized-By Cytolytics T Lymphocytes on a Human Melanoma", Science 254: 1643-1647 (Dec. 1991).
Traversari et al., "A Nonapeptide Encoded by Human Gene MAGE-1-Is Recognized on HLA-A1 By Cytolytic T Lymphocytes Directed Against Tumor Antigen MZ2-E". J.Exp.Med. 176: 1453-1457 (1992).
Kumar et al., Proc. Natl. Acad. Sci. 87:1337-1341, Feb. 1990.
Salgaller et al. Cancer Immunology and Immunotherapy 39:105-116, Aug. 1994.
Khanna et al. J. Exp. Med. 176:169-176, Jul. 1992.

Affiliated with

Also associated with

Rating

Isolated cytolytic T cells specific for complexes of MAGE relate does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isolated cytolytic T cells specific for complexes of MAGE relate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated cytolytic T cells specific for complexes of MAGE relate will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1607035