Isolated components of dense microspheres derived from mammalian

Details Isolated components of dense microspheres derived from mammalian Isolated components of dense microspheres derived from mammalian

1993-12-17

1996-06-11

Scheiner, Toni R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

424570, 530300, 530350, 530412, 530839, A61K 3900

Patent

active

055253393

ABSTRACT:
DMS present in the brain of individuals susceptible to cerebral amyloidosis disintegrate into DMS components to form cerebral amyloid plaques and other DMS components that are removed from the brain via circulating bodily fluids. Detecting the presence of these removed DMS components in circulating bodily fluids provides a diagnostic mechanism to determine the onset of cerebral amyloid plaque formation. Antibodies also can be raised against isolated DMS components and subsequently utilized in a diagnostic method capable of detecting the onset of cerebral amyloid plaque formation.

REFERENCES:
patent: 4816416 (1989-03-01), Averback
patent: 5100645 (1992-03-01), Ali-Khan et al.
patent: 5231170 (1993-07-01), Averback
Averback, "Morphometric and Anatomical Correlation of Dense Microsphere and Senile Plaque Formation . . .," The Canadian Journal of Neurological Sciences 9(2) 283-284 (May 1982).
Averback, "The Dense Microsphere: A Newly Delineated Orgin of the Senile Plaque in Human Brain" 912):284 (May 1982).
Averback, "Ultrastructural Studies of the Orgin and Growth of Dense Microsphere in Normal Human . . ." Canadian Journal of Neurological Sciences 9(2): 290-291 (May 1982).
Averback, "Quantitative Correlations of Dense Microspheres and Senile Plaques in Alzheimer Disease," Neurology 32(2): A227 (1982).
Averback "Immunofluorescent Staining of Dense Microspheres in Human Brain", Arch Pathol Lab Med vol. 106, Aug. 1982 106: 394-396.
Gaskin, "Autoantibodies to Neurofibrillary Tangles and Brain Tissue in Alzeheimer's Disease", Journal Ex. Med. 165:245-250 (Jan. 1987).
Davies, "Preparation of antigens from tissues and fluids", Handbook of Experimental Immunology, 3rd Edition, pp. 4.1-4.16. (Blackwell Scienific Publications, Oxford), 1978.
Laemmli, "Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4", Nature, 227: 680-685(Aug. 15, 1970).

Affiliated with

Also associated with

Rating

Isolated components of dense microspheres derived from mammalian does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isolated components of dense microspheres derived from mammalian, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated components of dense microspheres derived from mammalian will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-350337