Isolated complexes of endotoxin and MD-2

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S002600, C424S078310

Reexamination Certificate

active

10715876

ABSTRACT:
Applicants have produced and isolated water soluble complexes of endotoxin and MD-2.

REFERENCES:
patent: 3561444 (1971-02-01), Boucher
patent: 3703173 (1972-11-01), Dixon
patent: 4624251 (1986-11-01), Miller
patent: 4635627 (1987-01-01), Gam
patent: 4962091 (1990-10-01), Eppstein et al.
patent: 2002/0192217 (2002-12-01), Calandra et al.
patent: 2003/0119720 (2003-06-01), Khan et al.
patent: 2003/0175762 (2003-09-01), Nunez et al.
patent: 2003/0232352 (2003-12-01), Schwartz et al.
patent: 2003319734 (2003-11-01), None
patent: WO 94/07529 (1994-04-01), None
patent: WO 97/19688 (1997-06-01), None
Viriyakosol et al. MD-2 binds to bacterial lipopolysaccharide. J Biol Chem. Oct. 12, 2001;276(41):38044-51. Epub Aug. 10, 2001.
Abreu et al., “TLR4 and MD-2 Expression Is Regulated by Immune-mediated Signals in Human Intestinal Epithelial Cells,”J. Biol. Chem., 2002, 277(23):20431-20437.
Abreu et al., “Decreased Expression of Toll-Like Receptor-4 and MD-2 Correlates with Intestinal Epithelial Cell Protection Against Dysregulated Proinflammatory Gene Expression in Response to Bacterial Lipopolysaccharide,”J. Immunol., 2001, 167:1609-1617.
Akashi et al., “Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2: Higher Affinity than That with MD-2 or CD14,”J. Exp. Med., 2003, 198(7):1035-1042.
Akashi et al., “Cutting Edge: Cell Surface Expression and Lipopolysaccharide Signaling Via the Toll-Like Receptor 4-MD-2 Complex on Mouse Peritoneal Macrophages,”J. Immunol., 2000, 164:3471-3475.
Altschul et al., “Basic Local Alignment Search Tool,”J. Mol. Biol., 1990, 215:403-410.
Altschul et al., “Gapped BLAST and PSI-BLAST: a new generation of protein database search programs,”Nucl. Acids Res., 1997, 25(17):3389-3402.
Anderson et al., “A simple method for the rapid generation of recombinant adenovirus vectors,”Gene Ther., 2000, 7:1034-1038.
Anderson, “Toll signaling pathways in the innate immune response,”Curr. Opin. Immunol., 2000, 12:13-19.
Arbour et al., “TLR4 mutations are associated with endotoxin hyporesponsiveness in humans,”Nat. Genet., 2000, 25:187-191.
Bacchi et al., “Polyamine metabolism in the Microsporidia,” Biochemical Society Transactions, 2003, 31(2):420-423.
Bals et al., “Human β-Defensin 2 Is a Salt-sensitive Peptide Antibiotic Expressed in Human Lung,”J. Clin. Invest., 1998, 102(5):874-880.
Bandi et al., “NontypeableHaemophilus influenzaein the Lower Respiratory Tract of Patients with Chronic Bronchitis,”Am. J. Respir. Crit. Care Med., 2001, 164:2114-2119.
Becker et al., “CD14-dependent Lipopolysaccharide-induced β-Defensin-2 Expression in Human Tracheobronchial Epithelium,”J. Biol. Chem., 2000, 275(38):29731-29736.
Beutler and Poltorak, “Sepsis and evolution of the innate immune response,”Crit. Care Med., 2001, 29(7)(Suppl.):S2-S7.
Beutler and Rietschel, “Innate immune sensing and its roots: the story of endotoxin,”Nat. Rev. Immunol., 2003, 3:169-176.
Bustin “Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays,”J. Mol. Endocrinol., 2000, 25:169-193.
Corpet, “Multiple sequence alignment with hierarchical clustering,”Nucl. Acids Res., 1988, 16(22):10881-10890.
Correia et al., “Lipopolysaccharide Is in Close Proximity to Each of the Proteins in Its Membrane Receptor Complex,”J. Biol. Chem., 2001, 276(24):21129-21135.
Denning et al., “PseudomonasPyocyanin Increases Interleukin-8 Expression by Human Airway Epithelial Cells,”Infect. Immun., 1998, 66(12):5777-5784.
Douwes et al., “Biological agents—recognition,”Modern Industrial Hygiene, vol. 2, 2003, J.L. Perkins (ed.), ACGIH, Cincinnati, pp. 219-292.
Frick et al., “Haemophilus influenzaeStimulates ICAM-1 Expression on Respiratory Epithelial Cells,”J. Immunol., 2000, 164:4185-4196.
Ganz, “Antimicrobial polypeptides in host defense of the respiratory tract,”J. Clin. Invest., 2002, 109:693-697.
García et al., “Human β-defensin 4: a novel inductible peptide with a specific salt-sensitive spectrum of antimicrobial activity,”FASEB J., 2001, 15:1819-1821.
Giardina et al., “Construction of Acetate Auxotrophs ofNeisseria meningitidesto Study Host-Meningococcal Endotoxin Interactions,”J. Biol. Chem., 2001, 276(8):5883-5891.
Gioannini et al., “Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations,”Proc. Natl. Acad. Sci. USA, 2004, 101(12):4186-4191.
Gioannini et al., “An Essential Role for Albumin in the Interaction of Endotoxin with Lipopolysaccharide-binding Protein and sCD14 and Resultant Cell Activation,”J. Biol. Chem., 2002, 277(49):47818-47825.
Gioannini et al., “Regulation of interactions with endotoxin with host cells,”J. Endotoxin Res., 2003, 9(6):401-408.
Gottar et al., “TheDrosophilaimmune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein,”Nature, 2002, 416:640-644.
Hailman et al., “Lipopolysaccharide (LPS)-binding Protein Accelerates the Binding of LPS to CD14,”J. Exp. Med., 1994, 179:269-277.
Harder et al., “MucoidPseudomonas aeruginosa, TNF-α, and IL-1β, but Not IL-6, Induce Human β-Defensin-2 in Respiratory Epithelia,”Am. J. Respir. Cell Mol. Biol., 2000, 22:714-721.
Harder et al., “Isolation and Characterization of Human β- Defensin-3, a Novel Human Inducible Peptide Antibiotic,”J. Biol. Chem., 2001, 276(8):5707-5713.
Harder et al., “A peptide antibiotic from human skin,”Nature, 1997, 387:861.
Higgins and Sharp, “Fast and sensitive multiple sequence alignments on a microcomputer,”CABIOS, 1989, 5(2):151-153.
Higgins and Sharp, “CLUSTAL: a package for performing multiple sequence alignment on a microcomputer,”Gene, 1988, 73:237-244.
Hoffman et al., “Phylogenetic Perspectives in Innate Immunity,”Science, 1999, 284:1313-1318.
Huang et al., “Parallelization of a local similarity algorithm,”CABIOS, 1992, 8(2):155-165.
Inzana et al., “Phase Variation and Conservation of Lipooligosaccharide Epitopes inHaemophilus somnus,”Infect. Immun., 1997, 65(11):4675-4681.
Iovine et al., “The Carboxyl-terminal Domain of Closely Related Endotoxin-binding Proteins Determines the Target of Protein-Lipopolysaccharide Complexes,”J. Biol. Chem., 2002, 277(10):7970-7978.
Janeway Jr. and Medzhitov, “Innate Immune Recognition,”Annu. Rev. Immunol., 2002, 20:197-216.
Jia et al., “Discovery of new human β-defensins using a genomics-based approach,”Gene, 2001, 263:211-218.
Jia et al., “Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2,”Am. J. Physiol. Lung Cell Mol. Physiol., 2004, 287:L428-L437.
Jiang et al., “Cutting Edge: Lipopolysaccharide Induces Physical Proximity Between CD14 and Toll-Like Receptor 4 (TLR4) Prior to Nuclear Translocation of NF-κB1,” J. Immunol., 2000, 165:3541-3544.
Karlin and Altschul, “Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes,”Proc. Natl. Acad. Sci. USA, 1990, 87:2264-2268.
Karlin and Altschul, “Applications and statistics for multiple high-scoring segments in molecular sequences,”Proc. Natl. Acad. Sci. USA, 1993, 90:5873-5877.
Karp et al., “An In Vitro Model of Differential Human Airway Epithelia,”Meth. Mol. Biol., 2002, 188:115-137.
Kawasaki et al., “Involvement of TLR4/MD-2 complex in species-specific lipopolysaccharide-mimetic signal transduction by Taxol,”J. Endotoxin Res., 2001, 7(3):232-236.
Kawasaki et al., “Identification of Mouse M

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Isolated complexes of endotoxin and MD-2 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isolated complexes of endotoxin and MD-2, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated complexes of endotoxin and MD-2 will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3809876

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.