Isolated atrial peptide-degrading enzyme and novel compounds use

Details Isolated atrial peptide-degrading enzyme and novel compounds use Isolated atrial peptide-degrading enzyme and novel compounds use

1991-06-07

1993-11-16

Cashion, Jr., Merrell C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

930 21, A61K 3702

Patent

active

052625214

ABSTRACT:
A novel atrial peptide-degrading enzyme (ADE) is provided in isolated, purified form. The enzyme has a molecular weight of approximately 160,000 Daltons as measured by gel filtration chromatography, and is effective to cleave atrial peptides such as APII, APIII and ANF. Also provided are novel compounds useful as inhibitors of the enzyme and thus useful as blood pressure lowering agents, pharmaceutical compositions containing the inhibitors, and methods of using the inhibitors.

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