Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Patent
1995-09-28
1997-04-08
Hutzell, Paula K.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
530350, C07K 14705, A61K 3900
Patent
active
056185340
ABSTRACT:
An antigen which is specific to vascular endothelium is described. Described is a cell surface antigen which consists of four subunits; of 190, 145, 125 and 110 kd as determined by SDS-PAGE under reducing conditions as is a monoclonal antibody specific to this antigen. Uses, both diagnostic and therapeutic, are also described.
REFERENCES:
patent: 5342757 (1994-08-01), Garin-Chesa et al.
Rettig et al., "Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer", Proc. Natl. Acad. Sci. USA 89: 10832-10836 (11-92).
Schlingemann et al., "Differential Expression of Markers for Endothelial Cells, Pericytes and Basal Lamina in the Micro-vasculature of Tumors and Granulation Tissue", Amer. J. Path. 138(6): 1335-1347 (1991).
Garin-Chesa et al., "Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers", Proc. Natl. Acad. Sci. USA 87: 7235-7239 (Sep.1990).
Ruiter et al., "Monoclonal Antibody-Defined Human endothelial Antigens as Vascular Markers", J. Invest. Derm. 93(2) (supp): 255-32S (Aug. 1989).
Goerdt et al., "Characterization And Differential Expression of an Endothelial Cell-Specific Surface Antign In Continuous And Sinusoidal Endothelia, In Skin Vascular Lesions And In Vitro", Expl. Cell Biol. 57: 185-192 (1989).
Garin-Chesa Pilar
Old Lloyd J.
Rettig Wolfgang J.
Sanz-Moncasi Maria P.
Stockert Elisabeth
Hutzell Paula K.
Memorial Sloan Kettering Cancer Center
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