Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-01-04
2005-01-04
Carlson, Karen Cochrane (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
06838435
ABSTRACT:
The present invention relates to isolated and recombinant antimicrobial peptides thrombocidin-1 (TC-1) and thrombocidin-2 (TC-2), or variants thereof, which comprise at least in part the sequence as shown in FIG.1indicated by the label TC-1 and TC-2, and have antimicrobial activity against gram-positive and gram-negative bacteria, for exampleEscherichia coli, Bacillus subtilis, Streptococcus sanguis, Streptococcus pneumoniae, Staphylococcus epidermis, andStaphylococcus aureus, and/or against fungi, for exampleCandida albicans, C. glabarata, Cryptococcus neoformans, Aspergillus flavus, A. fumigatus, andPseudoallescheriaspec. The invention further relates to the use of said peptides, or variants thereof, for the preparation of a medicament for the treatment of bacterial or fungal infections, such as endocarditis, in humans and animals and the use of said peptides, or variants thereof, in release systems for prevention of bacterial or fungal infections in humans and animals.
REFERENCES:
patent: 4725576 (1988-02-01), Pollock et al.
patent: 5073627 (1991-12-01), Curtis et al.
patent: 5656724 (1997-08-01), Daly et al.
patent: WO 9006321 (1990-06-01), None
patent: 9006321 (1990-06-01), None
patent: 9719173 (1997-05-01), None
Cimbollek M, Nies B, Wenz R, Kreuter J. Antibiotic-impregnated heart valve sewing rings for treatment and prophylaxis of bacterial endocarditis. Antimicrob Agents Chemother. Jun. 1996;40(6):1432-7.*
Harwig et al.; “Intramolecular disulfide bonds enhance the antimicrobial and lytic activities of protegrins at physiological sodium chloride concentrations”,Eur. J. Biochem.240, pp. 352-357 (1996).
Lindley et al.; “Synthesis and expression inEscherichia coliof the gene encoding monocyte-derived neutrophil-activating factor: Biological equivalence between natural and recombinant neutrophil-activating factor”;Proc. Natl. Acad. Sci. USA, vol. 85, pp. 9199-9203 (Dec. 1988).
Piers et al.; “Recombinant DNA procedures for producing small antimicrobial cationic peptides in bacteria”;Gene. 134, pp. 7-13 (1993).
Proudfoot et al.; “Structure and Bioactivity of Recombinant Human CTAP-III and NAP-2”;Journal of Protein Chemistry, vol. 16, No. 1, pp. 37-49 (1997).
Selsted et al.; “Determination of the Disulfide Array in the Human Defensin HNP-2” (A Covalently Cyclized Peptide);Journal of Biological Chemistry, vol. 264,No. 7, Mar. 5 Issue, pp. 4003-4007 (1989).
Yomogida et al.; “Involvement of Cysteine Residues in the Biological Activity of the Active Fragments of Guinea Pig Neutrophil Cationic Peptides”;Infection and Immunity, vol. 63, No. 6, pp. 2344-2346 (Jun. 1995); Amer. Society for Microbiology (1995).
Yeaman et al., Platelet Microbicidal Protein Alone and in Combination with Antibiotics ReducesStaphylococcus aureusAdherence to Platelets in Vitro, Aug. 1994, pp. 3416-3423.
Yeaman et al., Partial Characterization and Staphylocidal Activity of Thrombin-Induced Platelet Microbicidal Protein, Mar. 1992, pp. 1202-1209.
Dankert et al., Involvement of Bactericidal Factors from Thrombin-Stimulated Platelets in Clearance of Adherent Viridans Streptococci in Experimental Infective Endocarditis, Feb. 1995, pp. 663-671.
Zaat et al., Cell-Adherent Glucan Does Not Protect Endocarditis-Causing Viridans Streptococci Against Bactericidal Proteins from Human Blood Platelets, 1997, pp. 709-712.
Standiford et al., Role of Chemokines in Antibacterial Host Defense, 1997, pp. 220-241.
Harwig et al., Purification of Cysteine-Rich Bioactive Peptides from Leukocytes by Continuous Acid-Urea-Polyacrylamide Gel Electrophoresis, Feb. 1993, pp. 382-386.
Yeaman et al., Fluconazole and platelet microbicidal protein inhibit Candida adherence to platelets in vitro, Jul. 1997, p. 1.
Yeaman et al., Thrombin-induced rabbit platelet microbicidal protein in fungicidal in vitro, Mar. 1993, p. 1.
Dankert Jacob
Engbers Gerardus Henricus Maria
Feijen Jan
Krijgsveld Jeroen
Kuijpers Alma Johanna
Academisch Ziekenhuis bij de Universiteit van Amsterdam
Carlson Karen Cochrane
Nederlandse Organisatie Voor Wetenschappelijk Onderzoek
Snedden Sheridan K
Universiteit Twente
LandOfFree
Isolated and recombinant antimicrobial peptides... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Isolated and recombinant antimicrobial peptides..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated and recombinant antimicrobial peptides... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3374998