Isolated and purified human soluble guanylyl cyclase...

Details Isolated and purified human soluble guanylyl cyclase... Isolated and purified human soluble guanylyl cyclase...

2005-02-01

2005-02-01

Rao, Manjunath (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S004000, C435S006120, C435S019000, C435S183000, C435S252300, C435S320100, C435S325000, C530S350000, C536S023200, C536S023740, C536S023400, C536S023500

Reexamination Certificate

active

06849438

ABSTRACT:
The invention relates to the expression of the cDNA clone for sub-units a1 (hsGCa1) and b1 (hsGCb1) of human soluble guanylylcyclase and the subsequent purification of the active enzyme and use thereof, the medical application of the expression of this clone by gene transfer, in addition to antibodies against peptides derived from said sequence and the use thereof.

REFERENCES:
Giuili et al. (FEBS Lett, vol. 304(1):83-88).*
Zabel et al. (Biochem J., vol. 335(1):51-57, 1998).

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