Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active...
Reexamination Certificate
2007-05-08
2007-05-08
Naff, David M. (Department: 1651)
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
C424S078170, C424S486000, C435S180000, C514S772100, C514S772300
Reexamination Certificate
active
11112118
ABSTRACT:
Water soluble activated polymers are provided containing an active ethyl sulfone moiety having a reactive site located at the second carbon from the sulfone group. In an embodiment, a poly(ethylene glycol) (PEG) derivative is disclosed that is activated with the active ethyl sulfone moiety for selective attachment to thiol moieties on molecules and surfaces. The activated PEG is water soluble, hydrolytically stable for extended periods, and forms hydrolytically stable linkages with thiol moieties. The linkages generally are not reversible in reducing environments. The PEG derivative is useful for modifying the characteristics of substances including modifying biologically active molecules and surfaces for biocompatibility.
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Alston & Bird LLP
Naff David M.
Nektar Therapeutics AL, Corporation
Ware Deborah K.
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