Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-11-02
1998-03-10
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514370, 514377, 548181, 548233, 5483121, C07D41704, A61K 31425
Patent
active
057261970
ABSTRACT:
Compounds of the Formula: ##STR1## wherein: R.sup.1 and R.sup.2 are independently hydrogen or lower alkyl;
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patent: 4777181 (1988-10-01), Cohnen et al.
patent: 4918083 (1990-04-01), Berge et al.
Affinity of 2-(Tetrahydroisoquinolin-2-ylmethyl)-and 2-(Isoindolin-2-ylmethyl)imidazolines for .alpha.-Adrenoceptors. by Clark, et al., Journal of Medicinal Chemistry, 1990, vol. 33, No. 2, pp. 596-600.
Novel .alpha..sub.2 -adrenoceptor antagonists show selectivity for .alpha..sub.2A -and .alpha..sub.2B -adrenoceptor subtypes, by Young, et al., European Journal of Pharmacology, vol. 168 (1989) pp. 381-386.
Gawley, J. Org. Chem. 53, 5381 (1988).
Clark Robin D.
Spedding Michael
Gerstl Robert
Syntex (U.S.A.) Inc.
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