Isoindolinyl-alkyl-piperazines

Details Isoindolinyl-alkyl-piperazines Isoindolinyl-alkyl-piperazines

1984-07-11

1986-04-29

Lesmes, George F.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544360, 544373, 544364, C07D40306, A61K 31495

Patent

active

045857733

ABSTRACT:
The invention is generally concerned with isoindolinyl-alkylpiperazine compounds generally characterized by the formula ##STR1## wherein X is halogen or trifluoromethyl; n is an integer ranging from 2 to 5; Y is ##STR2## in which R.sub.1 is hydrogen, halogen, lower alkyl, lower alkoxy, trifluoromethyl, cyano; R.sub.2 is hydrogen, halogen, lower alkyl, lower alkoxy; and R.sub.3 is hydrogen, cyano. These compounds are useful as diuretic and/or antihypertensive agents.

REFERENCES:
patent: 3198798 (1965-08-01), Zinitz et al.
patent: 3579524 (1971-05-01), Van Dyke
Topliss, J. Med. Chem., vol. 15, 1006-10010, (1972).
Cornish et al., "The Diuretic Activity of Clorexolone and Some Related Phthalimides and 1-Oxoisoindolines", J. Pharm. Pharmacol., 18, 65-80 (1966).
Himori et al., "Antihypertensive Effects of a Combination of a Diuretic and a .beta.-Adrenoceptor Blocking Agent in Conscious Renal Hypertensive Dogs" (Chem. Abs. 90:97589t).
Suzuki et al., "Pharmacological Studies of Diuretics. V. Single and Combination Effects of Diuretic Agents in the Normal or Spontaneously Hypertensive Rats", (Chem. Abs. 81:58265d).

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