Isoindoline nitromethane derivatives

Details Isoindoline nitromethane derivatives Isoindoline nitromethane derivatives

1990-02-05

1992-03-17

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

540203, 540593, 540604, 544 52, 544 582, 544105, 544353, 544383, 544160, 546141, 546153, 546232, 546248, 548146, 548768, 548179, 548207, 548214, 548470, 548482, 548491, 548542, A61K 3140, C07D20944

Patent

active

050969188

ABSTRACT:
The invention concerns pharmaceutially useful heterocyclic nitromethane compounds of the formula I: ##STR1## in which ring Q is a heterocycle of 4 to 7 ring atoms, the fragment completing the ring Q having 2 to 5 atoms, one of which is carbon, oxygen, sulphur or a group of the formula --NRa--, and the remainder are carbon; Ra is hydrogen, (1-6C)alkyl, (2-6C)alkanoyl, trifluoroacetyl, phenyl, benzoyl, or phenyl(1-4C)alkyl, the latter three optionally substituted; and R.sup.1 R.sup.2 and R.sup.3 are independently hydrogen, hydroxy, (1-6C)alkyl, (1-6C)alkoxy, phenyl, phenoxy or phenyl(1-4C)alkyl, the last three optionally substituted, or two of R.sup.1, R.sup.2 and R.sup.3 situated on adjacent ring carbon atoms and together with said carbon atoms form a benzene ring fused to ring Q, the benzene ring itself optionally substituted, provided that when the fragment completion ring Q is of 3 atoms then at least one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen; and salts thereof. Other aspects of the invention include the production of the novel compounds by analogy processes and pharmaceutical compositions of the novel compounds and of N-(nitromethylsulphonyl)morpholine for use in the treatment of diabetic complications.

REFERENCES:
patent: 4053633 (1977-10-01), Goralski et al.
J. Organic Chemistry, 43:3101 (1978).
J. Prakt. Chem., 101:136-157 (1920) (Chemical Abstracts, vol. 15, pp. 1013-1014.
Rec. Trav. Chim. Pays Bas., 93:11-14 (1974).
Chemical Abstracts, vol. 59, Abstract No. 6341g.
J. Polymer Science, Polymer Chemistry Edition, 23:1963-1972 (1985).
J. Heterocyclic Chemistry, 14:1415-1416 (1977). )
Tetrahedron, 25:181-189 (1969).

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