Isoindolin-1-one derivative and antiarrhythmic agent

Details Isoindolin-1-one derivative and antiarrhythmic agent Isoindolin-1-one derivative and antiarrhythmic agent

1987-12-22

1989-07-18

Ceperley, Mary E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514278, 514318, 514323, 514339, 514416, 546 15, 546201, 546273, 548410, 548465, 548472, A61K 3140, C07D20946

Patent

active

048494410

ABSTRACT:
Isoindolin-1-one compounds represented by the following formula (I); ##STR1## {wherein n represents an integer of 1 to 6; m represents 0 or 1; R.sub.1, R.sub.2 and R.sub.3 are each independently hydrogen or lower alkyl, and when m is 1, R.sub.1 and one of R.sub.2 and R.sub.3 may form a five-membered or six-membered ring over N atom; X represents hydrogen or hydroxy; Ar represents naphthyl, pyridyl or substituted phenyl represented by the formula (II); Ar and X may form a lactone ring; ##STR2## [wherein Y represents carboxyl, lower alkoxycarbonyl, carbamoyl, N,N-lower alkyl-substituted carbamoyl or amino represented by the formula (III): ##STR3## (wherein R.sub.6 and R.sub.7 are each independently hydrogen, lower alkyl or lower alkanoyl); R.sub.4 and R.sub.5 are each independently hydrogen, lower alkyl, cyano or halogen]} or a pharmaceutically acceptable acid addition salt or metal salt thereof have an excellent antiarrhythmic activity.

REFERENCES:
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Arch. Int. Pharmacodyn. Ther., 185, 47 (1970); C. Hanna "Gitan, 2-(.beta.-Diethylaminoethyl)-3-Phenylphthalimidine Phosphate an Antitussive Agent".
Chemical Abstracts, vol. 76, No. 1, 1,18, Jan. 3, 1972, Columbus, Ohio, U.S.A. and related Sulkowski, et al. "Tetrahydropyrimidinyl- and Imidazolinylphenyl Ketones as Antidepressants and Diuretics", p. 346, col. 1, 2, Abstract-No. 3 893y.
Chemical Abstracts, vol. 83, No. 23,1,18, Dec. 8, 1975, Columbus, Ohio, U.S.A. and related Sulkowski, Theodore S. "Producing Anorexia Using Imidazolinyl Phenyl Carbonyl Compounds, Their Acid Addition Salts and Related Compounds", p. 473, col. 2, Abst. No. 193 362q.
Chemical Abstracts, vol. 72, No. 19, May 11, 1970, Columbus, Ohio, U.S.A. and related Houlihan, William J., "2-(2-Amino-ethyl)-3-(substitutedphenyl)-phthalimidines", p. 354, col. 1, Abstract No. 100 505y.
Chemical Abstracts, vol. 87, No. 1, 1,18 Jul. 4, 1977, Columbus, Ohio, U.S.A. and related Thomae, Dr. Karl, GmbH "Substituted arylalkylamines", p. 630, col. 1, Abstract-No. 23 039e.

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