Isoindoles having cardiovascular activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548477, A61K 3140, C07D20948

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active

053766733

ABSTRACT:
Isoindole compounds of the formula (I) ##STR1## wherein R.sub.1 represents hydrogen; C.sub.1 -C.sub.6 alkyl; benzyl optionally substituted with halogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, methylenedioxy; C.sub.2 -C.sub.8 aliphatic acyl; benzoyl optionally substituted with halogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, C.sub.2 -C.sub.6 alkanoyl, C.sub.2 -C.sub.6 alkanoyloxy, C.sub.1 -C.sub.4 alkyl, trifluoromethyl, methylenedioxy;

REFERENCES:
patent: 5189034 (1993-02-01), Sala et al.
Chemical Abstracts, vol. 108, No. 21, May 23, 1988, Columbus, Ohio, US; abstract No. 186566R, Y. Morisawa: "Preparation of Phthlimidines for Treatment of Angina Pectoris", p. 688.

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