Isoindole diuretic derivatives, compositions and use

Details Isoindole diuretic derivatives, compositions and use Isoindole diuretic derivatives, compositions and use

1983-10-13

1985-03-19

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514323, 514339, 544144, 546200, 546272, 548472, A61K 3140, A61K 31535, C07D20946, C07D41306

Patent

active

045059110

ABSTRACT:
The invention provides 3-oxoisoindole compounds useful as diuretics of the general formula ##STR1## wherein X is halogen or trifluoromethyl, A is alkylene (C.sub.2 -C.sub.4), R.sub.1 is alkyl, R.sub.2 is alkyl or phenylalkyl, or R.sub.1 and R.sub.2 taken together with nitrogen are piperidino, morpholino or pyridinyl.

REFERENCES:
patent: 3183243 (1965-05-01), Lee et al.
patent: 3579524 (1971-05-01), Van Dyke, Jr.
Cornish, et al., J. Pharm. Pharmacol., 18, (1966), pp. 65-80.
Himori, et al., Jpn. J. Pharmacol, 1978, 28(6), pp. 811-818, (Chem. Abs. 90:97589t).
Suzuki, et al., Nippon Yakurigaku Zasshi, 1972, 68(3), pp. 276-289, (Chem. Abs. 81: 58265d).

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