Isoindole derivatives and salts thereof and antitumor agent comp

Details Isoindole derivatives and salts thereof and antitumor agent comp Isoindole derivatives and salts thereof and antitumor agent comp

1990-10-30

1992-11-24

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514253, 514316, 514321, 514339, 514410, 544142, 544372, 546187, 546198, 546271, 548418, 548423, A61K 3140, A61K 31535, C07D48704, C07D49504

Patent

active

051662043

ABSTRACT:
A novel isoindole derivative represented by general formula [1] or a salt thereof: ##STR1## which has an excellent antitumor activity and low toxicity.

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Chemiker-Zeitung, (1988), 112, pp. 235-238, "1,4-Dihydro- und 2,4-Dihydropyrrolo[3,4-b]indole mit Donator-Gruppen in 3-Stellung[1]", Dyker et al.
J. Org. Chem., (1989), 54, pp. 824-828, "Synthesis of indolo[2,3-a]pyrrolo[3,4-c]carbazoles by Dougle Fischer Indolizations", Bergman et al.
Yakugaku Zasshi, (1968), 88, pp. 767-773, "Studies on Indole Derivatives. VII. Diels-Alder Reaction of 2-Oxo-4-methylthiopyrano-[2,3-b]. . . " Kobayashi et al.
Yakagaku Zasshi, (1969), 89, pp. 58-63, "Studies on Indole Derivatives. VIII. Synthesis of Thieno [2,3-B]indole Derivatives and Their . . . " Kobayashi et al.
Chimia, (1988), 42, pp. 180-183, "Constitution and Stereochemistry of the Diels-Alder Products from the Reaction of 1-Methylpyrano . . . " Pindur et al.
Chem. Pharm. Bull., (1984), 32, pp. 902-908, "Pyridazino[4,5-B]Carbazole: Synthese et Etude des Spectres de Resonance Magnetique Nucleaire" Lancelot et al.
Arm. Khim. ZH., (1968), 21, pp. 793-807.

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