Isoindole derivatives

Details Isoindole derivatives Isoindole derivatives

1984-11-01

1986-07-15

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40104

Patent

active

046007580

ABSTRACT:
Novel phthalimide intermediates are reduced to 5-sulfamoyl-6-halo-3-oxoisoindole compounds bearing a substituted 1-phenylalkyl-4-piperidinyl moiety as the isoindole N-substitutent. Preferred compounds such as 6-chloro-2,3-dihydro-3-oxo-2-[1-(phenylmethyl)-4-piperidinyl]-1H-isoindole -5-sulfonamide exhibit diuretic and antihypertensive properties.

REFERENCES:
patent: 3579524 (1971-05-01), Van Dyke
Topliss, J., J. Med. Chem., 15 (10), 1006 (1972).
Cornish, E., et al., J. Pharm. Pharmac., 18, 65-80, (1966).
Chem. Abstracts, 81:58265d, (1974) [Suzuki, et al., Nippon Yakurigaku Zasshi, 1972, 68, (3), 276-89].
Chem. Abstracts, 90:97589t, (1979), [Himori, et al., Jpn. J. Pharmacol. 1978, 28, (6), 811-18].

Affiliated with

Also associated with

Rating

Isoindole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isoindole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isoindole derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1741608