Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1993-03-22
1994-06-21
Cashion, Jr., Merrell C.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
A61K 3700, A61K 3702, C07K 500, C07K 700
Patent
active
053229266
ABSTRACT:
Thrombin inhibitors from the hirudin family which differ from the previously known hirudins by mutation in the protein chain, and a process for their preparation are described. The novel hirudins are distinguished by a high specific activity, high stability and good pharmacokinetics.
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Crause Peter
Engels Joachim
Habermann Paul
Kramer Martin
Scharf Matthias
Cashion Jr. Merrell C.
Davenport A. M.
Hoechst Aktiengesellschaft
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