Isoforms of the human vitamin D receptor

Details Isoforms of the human vitamin D receptor Isoforms of the human vitamin D receptor

2008-01-08

2008-01-08

Ulm, John (Department: 1649)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C530S350000

Reexamination Certificate

active

11156272

ABSTRACT:
The invention provides isolated polynucleotide molecules which encode novel isoforms of the human Vitamin D receptor (hVDR) or variant transcripts for hVDR. These isolated polynucleotide molecules may be utilized in, for example, methods of screening compounds for VDR agonist and/or antagonist activities.

REFERENCES:
Baker, A.R. et al. “Cloning and expression of full-length cDNA encoding human vitamin D receptor”, Proc. Nat. Acad. Sci. USA., 85:3294-3298, 1988.
Goto, H. et al., A single receptor identical with that from intestine/T47D cells mediates the action of 1,25-dihydroxyvitamin D-3 in HL-60 cellsBiochim Biophys Acta., 1132:103-108, 1992.
Miyamoto, K. et al., “Structural organization of the human vitamin D receptor chromosomal gene and its promoter”, Mol. Endocrin. 11(8): 1165-1179, 1997.
Crofts, L.A. et al., “Multiple promoters direct the tissue-specific expression of novel N-terminal variant human vitamin D receptor gene transcripts”, Proc. Nat. Acad. Sci. USA, 95:10529-10534, 1998.
Whitehead, R. H. et al., “A New Colon Carcinoma Cell Line (LIM1863) That Grows as Organoids With Spontaneous Differentiation into Crypt-Like Structures in Vitro”, Cancer Research 47; 2683-2689 (May 15, 1987).
Slater, M. et al., “Modulation of Growth factor Incorporation into ECM of Human Osteoblast-Like Cells in Vitro by 17β-estradiol”, Cancer Research 47; 2683-2689 (May 15, 1987).
Saijo, T. et al., “A Unique Mutation in the Vitamin D receptor Gene in Three Japanese Patients with Vitamin-D dependent Rickets Type II: Utility of Single-Strand Conformation Polymorphism Analysis for Heterozygous Carrier Detection”, Am. J. Hum. Genet. 49: 668-673 (1991).
Lu, Z. et al., “Cloning and Origin of the Two forms of Chicken Vitamin D Receptor”, Archives of Biochemistry and Biophysics vol. 339, No. 1; 99-106 (1997).
Ebihara, K. et al., “Intron Retention Generates A Novel Isoforms of the Murine Vitamin D Receptor That Acts in a Dominant Negative Way on the Vitamin D Signaling Pathway”, Molecular and Cellular Biology: 3393-3400 (1996).
MacDonald et al. Baculovirus-mediated expression of the human vitamine D receptor, Oct. 5, 1991, J. Biol. Chem. 266(28): 18808-18813.
Haussler M. R. et al., “The vitamin D hormone and its nuclear receptor: molecular actions and disease states”, Journal of Endocrinology, Bristol, GB, (1997), vol. 154, pp. s57-s73.
Jurutka, et al., “Human D receptor phosphorylation by casein kinase II at ser-208 potentiates transcriptional activation”, Proc. Natl. Acad. Sci. USA, (1996), vol. 93, pp. 3519-3524.
Sunn KL, et al., “Novel N-terminal variant of human VDR”, Molecular Endocrinology 15 (9): 1599-1609, (Sep. 2001).

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