Multicellular living organisms and unmodified parts thereof and – Plant – seedling – plant seed – or plant part – per se – Higher plant – seedling – plant seed – or plant part
Reexamination Certificate
2005-03-04
2008-10-07
Kallis, Russell (Department: 1638)
Multicellular living organisms and unmodified parts thereof and
Plant, seedling, plant seed, or plant part, per se
Higher plant, seedling, plant seed, or plant part
C800S298000, C800S312000, C435S419000
Reexamination Certificate
active
07432425
ABSTRACT:
Methods of genetically manipulating biology active 4′-O-methylated isoflavonoids have been found based upon the regiospecifity of isoflavone 7-OMT in vivo. Upon transformation and expression of an isoflavonoid O-methyltransferase gene, up-regulation of IOMT in the transgenic plants can be used to increase the accumulation of 4′-O-methylated isoflavonoid phytolalexins, providing for increased disease resistance to the plant. Similar methods can be used to increase accumulation of 4′-O-methylated isoflavonoid nutraceuticals in plants. For down-regulation of IOMT in plants that naturally make 4′O-isoflavonoid phytoalexins and 4′-O-methylated isoflavonoid nutraceuticals, IOMT gene sequences can be transformed in the antisense orientation.
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Dixon Richard A.
He Xian Z.
Kallis Russell
Sonnenschein Nath & Rosenthal LLP
The Samuel Roberts Noble Foundation
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