Isoflavone derivatives

Details Isoflavone derivatives Isoflavone derivatives

2005-10-25

2005-10-25

Dodson, Shelley A. (Department: 1616)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

C424S059000, C424S060000, C424S400000, C536S008000

Reexamination Certificate

active

06958156

ABSTRACT:
Isoflavones are modified by esterification at one or more of the C4′, C5, C6, and C7 positions to promote bioavailability, and especially to enhance solubility over the corresponding unesterified isoflavones. Preferred modifications produce a carboxylic acid hemiester or a phosphate ester which is biologically hydrolysable. Preferred starting isoflavones are genistin and daidzin, and still more preferably comprises an aglycone form such as genistein or daidzein. Esterified isoflavones may be employed therapeutically or prophylactically for a variety of conditions, provided as a dietary supplement, or added to natural or processed food-stuffs. Further preferred uses include incorporation of contemplated compounds into topical formulations, and especially cosmetic topical formulations.

REFERENCES:
patent: 5550152 (1996-08-01), Koch et al.
patent: 5679896 (1997-10-01), Nakamura et al.

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