Isoferritin as a marker for pathological pregnancy

Details Isoferritin as a marker for pathological pregnancy Isoferritin as a marker for pathological pregnancy

1990-06-12

1999-02-16

Eisenschenk, F C

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

514 8, 5303871, 530400, 530350, 53038824, 5303892, 435336, A61K 39395, C07K 1600, C07K 1400

Patent

active

058717358

ABSTRACT:
The present invention relates to a method of diagnosis of pathological pregnancy which relies on an evaluation of the amount of placental isoferritin (PLF) in the serum or amniotic fluid of a pregnant woman. Diagnosis may also be achieved by observation of percentages of PLF-bearing lymphocytes in the pregnant female. Detection of PLF levels is achieved by immunoassay with a PLF-specific antibody. Also described is a method of treating or preventing pathological pregnancies and transplant or graft rejection by administration of effective amounts of PLF and/or a PLF-specific antibody in combination with immunization.

REFERENCES:
patent: 4882270 (1989-11-01), Moroz
patent: 4954434 (1990-09-01), Moroz
Moroz et al., Clin. Chem. Acta, 148:111-118, 1985.
Sirota et al., Clin. Exp. Immunol., 76:1-6, 1989.
Kimmel et al J. Neurosurg 66:161-171 1987.
Harris et al TibTech 11:42-46 1993.

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