Isoferritin as a marker for pathological pregnancy

Details Isoferritin as a marker for pathological pregnancy Isoferritin as a marker for pathological pregnancy

1988-06-23

1990-09-04

Spiegel, Jack

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 14, 435 19, 435 21, 435 28, 436510, 436518, 436548, 436800, 436804, 436814, G01N 3353, G01N 33543, G01N 33577

Patent

active

049544349

ABSTRACT:
The present invention relates to a method of diagnosis of pathological pregnancy which relies on an evaluation of the amount of placental isoferritin (PLF) in the serum or amniotic fluid of a pregnant woman. Diagnosis may also be achieved by observation of percentages of PLF-bearing lymphocytes in the pregnant female. Detection of PLF levels is achieved by immunoassay with a PLF-specific anitbody. Also described is a method of treating or preventing pathological pregnancies and transplant or graft rejection by administration of effective amounts of PLF and/or a PLF-specific antibody in combination with immunization.

REFERENCES:
patent: 4278652 (1981-07-01), Niemann et al.
Voller, A., Diagnostic Horizons 2 No. 1:1-6 (1978).
Moroz, C. et al., Biological Abstracts 84(12): Abstract No. 119173 (1987).
Moroz et al., Clin. Chem. Acta, 148:111-118, 1985.

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