Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-04-28
1989-07-04
Fan, Jane T.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
549285, 549288, 548336, 548463, 548525, C07D31176
Patent
active
048452424
ABSTRACT:
Substituted isocoumarins, their preparation, their use in inhibiting serine proteases with trypsin-like, chymotrypsin-like and elastase-like specificity and their roles as anticoagulant agents, and anti-inflammatory agents.
REFERENCES:
patent: 2779762 (1957-01-01), Robertson et al.
Arora et al., CA 104:186277q.
Reaction of Homophthalic Acid With Phosphorus Pentachloride-V. B. Milevskaya, R. V. Belinskaya, & L. M. Yagupol'skii.
Isocourmarins: Part VI*-3-Alkoxy-4-Chloroisocoumarins, B. B. Tirookar & R. N. Usgaonkar.
Isocourmarins: Part XV-Nitro-& 7-Amino-Isocoumarins from 4- Nitrohomophthalic Acid Indira Choksey & R. N. Usgaonkar.
3-Alkoxy-7-Amino-4-chloroisocoumarins: A New Class of Suicide Substrates for Serine Protesases J. Wade Harper and James C. Powers*.
Reaction of Serine Proteases with Substituted 3-Alkoxy-4-Chloroisocoumarins and 3-Alkoxy-7-Amino-4-Chloroisocoumarins: New Reactive Mechanism-Based Inhibitors-J. W. Harper & J. C. Powers.
Reaction of Serine Proteases with Substituted Isocoumarins: Discovery of 3,4-Dichloroisocoumarin a New General Mechanism Based Serine Protease Inhibitor-J. W. Harper & J. C. Powers
New Mechanism-Based Serine Protease Inhibitors: Inhibition of Human Leukocyte Elastase, Procine Pancreatic Elastase, Human Leukocyte Cathepsin G, and Chymotrypsin by 3-Chloroisocoumarin and 3,3-Dichlorophthalide-J. W. Harper, Keiji Hemmi and J. C. Powers.
The Action of Phosphorous Pentachloride on Homophthalic Acid.
Kam Chih-Min
Powers James C.
Fan Jane T.
Georgia Tech Research Corporation
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