Isochromans

Details Isochromans Isochromans

1980-01-07

1982-09-28

Raymond, Richard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 60, 549406, C07D31176, C07D40504, C07D40904

Patent

active

043519423

ABSTRACT:
A process applicable to the preparation of a wide variety of novel polycyclic heterocycles having a newly-formed pyran ring is disclosed. According to the process an aromatic nucleus bearing an ethanol group, for example, 3,4-dimethoxyphenethyl alcohol, is condensed with an aldehyde or ketone or a protected aldehyde or ketone, for example, aminoactaldehyde diethyl acetal, in the presence of an acid catalyst to afford the polycyclic heterocycle, for example, 6,7-dimethoxy-1-isochromanmethylamine. The new heterocycles so formed are useful for preparing derivatives having antiinflammatory, antibacterial or antifungal activities.

REFERENCES:
van der Stelt et al., Chemical Abstracts, vol. 63 (1965) 5586b.
Proctor et al., J. Chem. Soc. (c), 1969, pp. 1000-1002.

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