Isocarbostyril derivatives

Details Isocarbostyril derivatives Isocarbostyril derivatives

1976-12-16

1978-12-12

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424250, 424258, 544363, C07D21716, C07D21724, C07D40112

Patent

active

041295650

ABSTRACT:
Isocarbostyrils of the formula ##STR1## wherein R.sub.1 represents a lower alkyl group having 1 to 4 carbon atoms, and R.sub.3 and R.sub.4, same or different, individually means hydrogen or an alkyl, aralkyl or cycloalkyl group provided at least either one of R.sub.3 and R.sub.4 should not be hydrogen, or R.sub.3 and R.sub.4 together with the adjacent nitrogen atom may form a heterocyclic ring, having anti-arrhythmic activity and low toxicity are prepared by reacting a 4-substituted isocarbostyril derivative of the formula ##STR2## wherein R.sub.1 is the same as defined above and R.sub.2 represents ##STR3## or its functional equivalent, e.g. --Ch.sub.2 --CH(OH)CH.sub.2 X in which X represents a halogen atom, with an alkyl amine of the general formula ##STR4## wherein R.sub.3 and R.sub.4 are same as defined above..

REFERENCES:
patent: 3910924 (1975-10-01), Tamura et al.
patent: 4013663 (1977-03-01), Westermann et al.

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