Isocarbacyclin derivatives and their pharmaceutically acceptable

Details Isocarbacyclin derivatives and their pharmaceutically acceptable Isocarbacyclin derivatives and their pharmaceutically acceptable

1990-09-14

1992-12-29

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 39, 560 56, 560119, 560121, 560256, 560 11, 556441, 554220, 554229, 504172, 504188, C07C17700, C07C32100, C07C 6974

Patent

active

051753383

ABSTRACT:
An isocarbacyclin derivative represented by the following formula [VII'] ##STR1## wherein A represents, a hydrocarbylcarboxylate group, a carboxymethoxycarbonyl group, an amide group, an acyloxymethyl group or a hydroxymethyl group; R.sup.4 represents H, a methyl group or a vinyl group; R.sup.5 represents a (substituted)alkyl group, a phenyl group, a phenoxy group or a cycloalkyl group; R.sup.e22 and R.sup.e32 represent H or a hydroxyprotecting group; n is 0 or 1;
and a pharmaceutically acceptable salt thereof.

REFERENCES:
Tetrahedron Letters, vol. 25, No. 44, pp. 5087-5090 1984; T. Mase et al.
Tetrahedron Letters, vol. 27, No. 7, pp. 845-846 1986; D. Ferroud et al.
Tetrahedron Letters, No. 36 (1972), pp. 3815-3817 J. Bagli et al.

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