Isobutylene polymer active compound release systems

Surgery – Controlled release therapeutic device or system – Osmotic or diffusion pumped device or system

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Details

604897, A61K 960, A61K 970, A61L 1500

Patent

active

046233466

ABSTRACT:
In a therapeutic system such as a plaster for administration of an active compound through the skin and comprising a covering layer which is essentially impermeable to the active compound an active compound reservoir layer and a protective layer which can be pulled off and which is essentially impermeable to the active compound, the improvement wherein the reservoir layer contains about 1-30% of active compound in an elastomer mixture comprising at least one of polyisobutylene, polybutadiene oil and paraffin oil, and a tackifying resin. Thereby the active compound can be released in regulated relatively large quantity over a prolonged period of time.

REFERENCES:
patent: 3996934 (1976-12-01), Zafforoni
patent: 4031894 (1977-06-01), Urguhart et al.
patent: 4201211 (1980-05-01), Chandrasekoran et al.
patent: 4455146 (1984-06-01), Noda et al.

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