Islet-specific homeoprotein and transcriptional regulator of ins

Details Islet-specific homeoprotein and transcriptional regulator of ins Islet-specific homeoprotein and transcriptional regulator of ins

1995-05-09

1999-09-21

Walsh, Stephen

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530324, 530352, C07K 1447

Patent

active

059555793

ABSTRACT:
The invention relates to a homeoprotein regulator of insulin gene expression having the characteristics of: binding to an element of an insulin gene promoter; being modulated by a Ca.sup.++ -dependent CaM kinase IV; and having homology to a nucleotide sequence encoded by a Hox gene complex. Also included within the invention are DNA sequences encoding the homeoprotein regulators of insulin gene expression, antibodies directed to the homeoprotein regulators of insulin gene expression, and diagnostic and therapeutic materials and utilities for the homeoprotein regulators of insulin gene expression.

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