Irritation-reducing ocular iontophoresis device

Details Irritation-reducing ocular iontophoresis device Irritation-reducing ocular iontophoresis device

2007-01-08

2009-06-16

Mendez, Manuel A (Department: 3763)

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

Reexamination Certificate

active

07548778

ABSTRACT:
The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoir, and a passive electrode, the device including at least one medication dissolved in non-saline water, the said solution having a pH lying in the range 6.5 to 8.5, the medication having a pKa lying in the range about 5.5 to about 9.5 and includes an active principle which is associated with an additive, such as a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion, and having an ionic form of valency greater than or equal to 1.

REFERENCES:
patent: 6001088 (1999-12-01), Roberts
patent: 7164943 (2007-01-01), Roy
patent: 0240189 (1987-10-01), None
patent: 2773320 (1999-07-01), None
Sarraf, et al.; “The Role of Iontophoresis in Ocular Drug Delivery;” Journal of Ocular Pharmacology; vol. 10, No. 1, 1994, pp. 69-81.
Halhal et al.; “Iontophoresis: from the lab to the bed side;” Experimental Eye Research 78, 2004; pp. 751-757.

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