Irreversible HIV protease inhibitors, compositions containing sa

Details Irreversible HIV protease inhibitors, compositions containing sa Irreversible HIV protease inhibitors, compositions containing sa

1996-06-06

1997-10-21

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514314, 514475, 546146, 546169, 549552, A61K 3147, A61K 31335, C07D21716, C07D21714

Patent

active

056796870

ABSTRACT:
The present invention relates to novel compounds of formula (I) which have inhibitory activity against human immunodeficiency virus ("HIV") protease, a process for the preparation thereof, and compositions for prevention or treatment of AIDS by HIV infection comprising the above compounds as active ingredients. ##STR1## wherein: R.sup.1 is an aromatic group, a nitrogen-containing aromatic group, C.sub.1-4 alkyl group optionally substituted with an aromatic group or a nitrogen-containing aromatic group, C.sub.1-4 alkoxy group optionally substituted with an aromatic group or a nitrogen-containing aromatic group;

REFERENCES:
patent: 5545750 (1996-08-01), Kempf et al.
patent: 5587388 (1996-12-01), Kim et al.

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